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PCSK9 / NARC1 Antibody, Rabbit PAb, Antigen Affinity Purified

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Mouse PCSK9 Antibody Product Information
Immunogen:Recombinant Mouse PCSK9 protein (Catalog#50251-M08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Mouse PCSK9 (rM PCSK9; Catalog#50251-M08H; NP_705793.1; Met 1-Gln 694). PCSK9 specific IgG was purified by mouse PCSK9 affinity chromatography .
Mouse PCSK9 Antibody Usage Guide
Specificity:Mouse PCSK9 / NARC1
Application:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse PCSK9. The detection limit for Mouse PCSK9 is approximately 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other PCSK9 Antibody Products
Reactivity: Human  
Application: ELISA  IHC-P  
  • Slide 1
10594-T24-100
10594-T24-200
10594-T24-50
100 µg 
200 µg 
50 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10594-MM01-50
    10594-MM01-100
    10594-MM01-200
    50 µg 
    100 µg 
    200 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10594-RP02-100
      10594-RP02-200
      10594-RP02-400
      100 µg 
      200 µg 
       
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10594-RM03-50
        10594-RM03-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10594-T16-100
          10594-T16-50
          10594-T16-200
          100 µg 
          50 µg 
          200 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10594-RP01-400
            10594-RP01-200
            10594-RP01-100
             
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              50251-RP01-100
              50251-RP01-200
              50251-RP01-400
              100 µg 
              200 µg 
               
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  
                50251-R106-50
                50251-R106-100
                50 µg 
                100 µg 
                Add to Cart
                Reactivity: Rat  
                Application: IHC-P  
                • Slide 1
                80005-MM04-50
                80005-MM04-100
                80005-MM04-200
                50 µg 
                100 µg 
                200 µg 
                Add to Cart
                Reactivity: Rat  
                Application: ELISA  
                  80005-RP01-100
                  80005-RP01-200
                  80005-RP01-400
                  100 µg 
                  200 µg 
                   
                  Add to Cart
                  Reactivity: Rat  
                  Application: ELISA  
                    80005-RP02-50
                    80005-RP02-100
                    80005-RP02-200
                    50 µg 
                    100 µg 
                    200 µg 
                    Add to Cart
                    Reactivity: Rat  
                    Application: ELISA  
                      80005-MM03-50
                      80005-MM03-100
                      80005-MM03-200
                      50 µg 
                      100 µg 
                      200 µg 
                      Add to Cart
                      PCSK9/NARC1 Background

                      Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

                      References

                      Mouse PCSK9/NARC1 References
                    • Sseidah, N.G. et al., 2003, Proc. Natl. Acad. Sci. USA. 100: 928-933.
                    • Beyer, T.P. et al., 2007, J. Lipid. Res. 48: 1488-1498
                    • Shan, L. et al., 2008, Biochem. Biophys. Res. Commun. 375: 69-73.
                    • Benjannet, S. et al., 2005, J. Biol. Chem. 279: 48865-48875.
                    • Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.
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                      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"