Anti-PCSK9 Antibody

Cat: 10594-RP02
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All PCSK9 Reagents
Anti-PCSK9 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PCSK9 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human PCSK9
Immunogen
Recombinant Human PCSK9 protein (Catalog#10594-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human Proprotein Convertase 9 (rhPCSK9; Catalog#10594-H08H; aa 1-692; NP_777596.2). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PCSK9 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PCSK9 Antibody Alternative Names
Anti-FH3 Antibody;Anti-HCHOLA3 Antibody;Anti-LDLCQ1 Antibody;Anti-NARC-1 Antibody;Anti-NARC1 Antibody;Anti-PC9 Antibody
PCSK9 Background Information

Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

References

Full Name
proprotein convertase subtilisin/kexin type 9
References
  • Sseidah, N.G. et al., 2003, Proc. Natl. Acad. Sci. USA. 100: 928-933.
  • Beyer, T.P. et al., 2007, J. Lipid. Res. 48: 1488-1498
  • Shan, L. et al., 2008, Biochem. Biophys. Res. Commun. 375: 69-73.
  • Benjannet, S. et al., 2005, J. Biol. Chem. 279: 48865-48875.
  • Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PCSK9 Antibody Mouse Monoclonal ELISA 80005-MM03
    Anti-PCSK9 Antibody Rabbit Polyclonal ELISA 80005-RP02
    Anti-PCSK9 Antibody Mouse Monoclonal ELISA(Cap) 80005-MM06
    Anti-PCSK9 Antibody Mouse Monoclonal IHC-P 80005-MM04
    Anti-PCSK9 Antibody Rabbit Monoclonal ELISA(Det) 80005-R007
    Anti-PCSK9 Antibody Rabbit Polyclonal ELISA 80005-RP01
    Anti-PCSK9 Antibody Rabbit Polyclonal ELISA,IHC-P,ICC/IF,IF 50251-T26
    Anti-PCSK9 Antibody Rabbit Monoclonal ELISA 50251-R106
    Anti-PCSK9 Antibody Rabbit Monoclonal ELISA(Cap) 50251-R214
    Anti-PCSK9 Antibody Rabbit Polyclonal ELISA 50251-RP01
    Anti-PCSK9 Antibody Rabbit Polyclonal ELISA 50251-RP02
    Anti-PCSK9 Antibody Rabbit Polyclonal ELISA 10594-T16
    Anti-PCSK9 Antibody Rabbit Monoclonal ELISA 10594-RM03
    Anti-PCSK9 Antibody Mouse Monoclonal ELISA 10594-MM01
    Anti-PCSK9 Antibody Rabbit Polyclonal ELISA 10594-RP01
    Anti-PCSK9 Antibody Rabbit Polyclonal ELISA,IHC-P 10594-T24
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