Anti-PCSK1 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human PCSK1 protein (Catalog#10129-H08H)
Produced in rabbits immunized with purified, recombinant Human PCSK1 (rh PCSK1; Catalog#10129-H08H; NP_000430.3; Met 1-Arg 617). PCSK1 specific IgG was purified by human PCSK1 affinity chromatography
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PCSK1 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-PCSK1 Antibody Alternative Names
Anti-BMIQ12 Antibody;Anti-NEC1 Antibody;Anti-PC1 Antibody;Anti-PC3 Antibody;Anti-SPC3 Antibody
PCSK1 Background Information
Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is an enzyme which belongs to the peptidase S8 family and Furin subfamily. PCSK1 is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleave after a single arginine. It binds to a protein known as proSAAS, which also represents its endogenous inhibitor. PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. PCSK1 substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Defects in PCSK1 are the cause of proprotein convertase 1 deficiency (PC1 deficiency). PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction. It is due to impaired processing of prohormones.
proprotein convertase subtilisin/kexin type 1
Jackson RS. et al., 2003, J. Clin. Invest. 112:1550-60. Farooqi I.S. et al., 2007, J. Clin. Endocrinol. Metab. 92: 3369-73. Benzinou,M. et al., 2008,Nat Genet. 40 (8):943-5. Benzinou M. et al., 2008, Nat. Genet. 40:943-5. Renström F, et al., 2009, Hum. Mol. Genet. 18 (8): 1489-96.