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PBK/TOPK Protein, Antibody, ELISA Kit, cDNA Clone

PBK/TOPK Related Areas

PBK/TOPK Related Pathways

PBK/TOPK Related Product

    PBK/TOPK Summary & Protein Information

    PBK/TOPK Background

    Gene Summary: This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis
    General information above from NCBI
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
    Enzyme regulation: Activated by phosphorylation (By similarity).
    Subunit structure: Interacts with DLG1 and TP53.
    Tissue specificity: Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.
    Post-translational: Phosphorylated; in a cell-cycle dependent manner at mitosis.
    Sequence similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
    Contains 1 protein kinase domain.C
    General information above from UniProt

    PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.This mitotic kinase phosphorylates MAP kinase p38 and seems to be active in mitosis. When phosphorylated, PBK forms a protein-protein interaction with tumor suppressor p53 (TP53), leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. The expression level of PBK is thus upregulated in a variety of neoplasms including hematological malignancies.

    PBK/TOPK Alternative Name

    PBK/TOPK Related Studies

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