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PDK / PDZ binding kinase / TOPK Antibody, Rabbit PAb, Antigen Affinity Purified

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    Human PBK/TOPK Antibody Product Information
    Immunogen:Recombinant Human PBK protein (Catalog#10729-H08B)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Human PBK / TOPK (rh PBK; Catalog#10729-H08B; NP_060962.2; Met 1-Val 322). PBK specific IgG was purified by human PBK affinity chromatography.
    Other PBK/TOPK Antibody Products
    PBK/TOPK Background

    PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.This mitotic kinase phosphorylates MAP kinase p38 and seems to be active in mitosis. When phosphorylated, PBK forms a protein-protein interaction with tumor suppressor p53 (TP53), leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. The expression level of PBK is thus upregulated in a variety of neoplasms including hematological malignancies.

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