Actopaxin, also known as alpha-parvin or parva, belongs to the parvin family. Parva is widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. Parva contains 2 CH (calponin-homology) domains and probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Parva interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Parva binds directly to both F-actin and paxillin LD1 and LD4 motifs. Parva also exhibits robust focal adhesion localization in several cultured cell types but is not found along the length of the associated actin-rich stress fibers. Parva is absent from actin-rich cell-cell adherens junctions.
PARVA ELISA Pair sets
PARVA cDNA Clones
CH-ILKBP, MXRA2, actopaxin, alpha-parvin, calponin-like integrin-linked kinase-binding protein, matrix-remodeling-associated protein 2 [Homo sapiens]
MNCb-0301, 2010012A22Rik, 5430400F08Rik, AI225929, AU042898, Actp, CH-ILKBP, Parvin, actopaxin, alpha-parvin [Mus musculus]
Entrez Gene summary for PARVA:
This PARVA gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. Parva is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]
OMIM - description for PARVA:
Members of the parvin family, including PARVA, are actin-binding proteins associated with focal contacts.
Wikipedia summary for PARVA:
Alpha-parvin is a protein that in humans is encoded by the PARVA gene.
Parva belongs to the parvin family. Parva contains 2 CH (calponin-homology) domains.
Parva interacts with TGFB1I1. Parva interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Parva interacts with ARHGAP31.
|Subcellular location:||Cell junction › focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm › cytoskeleton. Note: Constituent of focal adhesions.|
Parva is widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
General information above from UniProt
Parva probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Plays a role in ciliogenesis.
- Parva plays probably a role in the regulation of cell adhesion and cytoskeleton organisation
- Parva is actin-binding protein associated with focal contacts
- homolog to murine Parva
- homolog to Drosophila CG12533
- homolog to C.elegans pat-6
- paralog to PARVB
- paralog to PARVG