PARVA (Actopaxin)

Actopaxin, also known as alpha-parvin or parva, belongs to the parvin family. Parva is widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. Parva contains 2 CH (calponin-homology) domains and probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Parva interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Parva binds directly to both F-actin and paxillin LD1 and LD4 motifs. Parva also exhibits robust focal adhesion localization in several cultured cell types but is not found along the length of the associated actin-rich stress fibers. Parva is absent from actin-rich cell-cell adherens junctions.

PARVA (Actopaxin) Alternative Names

CH-ILKBP, MXRA2, actopaxin, alpha-parvin, calponin-like integrin-linked kinase-binding protein, matrix-remodeling-associated protein 2 [Homo sapiens]

MNCb-0301, 2010012A22Rik, 5430400F08Rik, AI225929, AU042898, Actp, CH-ILKBP, Parvin, actopaxin, alpha-parvin [Mus musculus]

Summaries for PARVA (Actopaxin)

Entrez Gene summary for PARVA:

This PARVA gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. Parva is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]

OMIM - description for PARVA:

Members of the parvin family, including PARVA, are actin-binding proteins associated with focal contacts.

Wikipedia summary for PARVA:

Alpha-parvin is a protein that in humans is encoded by the PARVA gene.

Human PARVA (Actopaxin) Protein General Information

 

• Protein names: Alpha-parvin
• Sequence length: 372 AA.
• Sequence similarities: Parva belongs to the parvin family. Parva contains 2 CH (calponin-homology) domains.
• Subunit structure: Parva interacts with TGFB1I1. Parva interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Parva interacts with ARHGAP31.
• Subcellular location: Cell junction › focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm › cytoskeleton. Note: Constituent of focal adhesions.
• Tissue specificity: Parva is widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.

General information above from UniProt

Function for PARVA (Actopaxin) Protein

UniProtKB:

Parva probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Plays a role in ciliogenesis.

Genatlas:

• Parva plays probably a role in the regulation of cell adhesion and cytoskeleton organisation
• Parva is actin-binding protein associated with focal contacts

Homology for human PARVA (Actopaxin)

• homolog to murine Parva
• homolog to Drosophila CG12533
• homolog to C.elegans pat-6
• paralog to PARVB
• paralog to PARVG