Anti-PARP Antibody

Cat: 11040-RP02
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Anti-PARP Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PARP Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human PARP
Immunogen
Recombinant Human PARP1 protein (Catalog#11040-H08B)
Preparation
Produced in rabbits immunized with purified, recombinant Human PARP1 (rh PARP1; Catalog#11040-H08B; NP_001609.2; Met 1-Trp 1014). PARP1 specific IgG was purified by human PARP1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PARP Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PARP Antibody Alternative Names
Anti-ADPRT Antibody;Anti-ADPRT1 Antibody;Anti-ARTD1 Antibody;Anti-pADPRT-1 Antibody;Anti-PARP Antibody;Anti-PARP-1 Antibody;Anti-PPOL Antibody
PARP Background Information

Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of NAD+ is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. The poly(ADP-ribosyl)ation modification is critical for a wide range of processes, including DNA repair, regulation of chromosome structure, transcriptional regulation, mitosis and apoptosis. PARP1 is demonstrateed to mediate the poly(ADP-ribose) ation of APLF (aprataxin PNK-like factor) and CHFR (checkpoint protein with FHA and RING domains), two representative proteins involved in the DNA damage response and checkpoint regulation. Further, It has been suggested that DNA-dependent protein kinase (DNA-PK), another component of DNA repair, suppresses PARP activity, probably through direct binding and/or sequestration of DNA-ends which serve as an important stimulator for both enzymes. PARP1 inhibitors is thus proposed as a targeted cancer therapy for recombination deficient cancers, such as BRCA2 tumors.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
poly (ADP-ribose) polymerase 1
References
  • Malanga M. et al., 1998, J Biol Chem. 273: 11839-11843.
  • Ariumi Y. et al., 1999, Oncogene. 18: 4616-4625.
  • Helleday T. et al., 2005, Cell Cycle. 4: 1176-1178.
  • Ahell I. et al., 2008, Nature. 451: 81-85.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PARP Antibody Rabbit Polyclonal ELISA 11040-RP01
    Anti-PARP Antibody Rabbit Polyclonal WB,IHC-P,ICC/IF,IF,IP 100984-T46
    Anti-PARP Antibody Mouse Monoclonal WB,IHC-P,IP 11040-MM04
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