Anti-PARP Antibody

Cat: 11040-RP02
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All PARP Reagents
Anti-PARP Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PARP Antibody
Validated applications
Species reactivity
Reacts with: Human
Human PARP
Recombinant Human PARP1 protein (Catalog#11040-H08B)
Produced in rabbits immunized with purified, recombinant Human PARP1 (rh PARP1; Catalog#11040-H08B; NP_001609.2; Met 1-Trp 1014). PARP1 specific IgG was purified by human PARP1 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PARP Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PARP Antibody Alternative Names
Anti-ADPRT Antibody;Anti-ADPRT1 Antibody;Anti-ARTD1 Antibody;Anti-pADPRT-1 Antibody;Anti-PARP Antibody;Anti-PARP-1 Antibody;Anti-PPOL Antibody
PARP Background Information

Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of NAD+ is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. The poly(ADP-ribosyl)ation modification is critical for a wide range of processes, including DNA repair, regulation of chromosome structure, transcriptional regulation, mitosis and apoptosis. PARP1 is demonstrateed to mediate the poly(ADP-ribose) ation of APLF (aprataxin PNK-like factor) and CHFR (checkpoint protein with FHA and RING domains), two representative proteins involved in the DNA damage response and checkpoint regulation. Further, It has been suggested that DNA-dependent protein kinase (DNA-PK), another component of DNA repair, suppresses PARP activity, probably through direct binding and/or sequestration of DNA-ends which serve as an important stimulator for both enzymes. PARP1 inhibitors is thus proposed as a targeted cancer therapy for recombination deficient cancers, such as BRCA2 tumors.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
poly (ADP-ribose) polymerase 1
  • Malanga M. et al., 1998, J Biol Chem. 273: 11839-11843.
  • Ariumi Y. et al., 1999, Oncogene. 18: 4616-4625.
  • Helleday T. et al., 2005, Cell Cycle. 4: 1176-1178.
  • Ahell I. et al., 2008, Nature. 451: 81-85.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PARP Antibody Rabbit Polyclonal ELISA 11040-RP01
    Anti-PARP Antibody Rabbit Polyclonal WB,IHC-P,ICC/IF,IF,IP 100984-T46
    Anti-PARP Antibody Mouse Monoclonal WB,IHC-P,IP 11040-MM04
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