All PARK7 / DJ-1 reagents are produced in house and quality controlled, including 3 PARK7 / DJ-1 Antibody, 47 PARK7 / DJ-1 Gene, 1 PARK7 / DJ-1 IPKit, 1 PARK7 / DJ-1 Protein, 2 PARK7 / DJ-1 qPCR. All PARK7 / DJ-1 reagents are ready to use.
Recombinant PARK7 / DJ-1 proteins are expressed by E. coli with fusion tags as C-His.
PARK7 / DJ-1antibodies are validated with different applications, which are WB, ELISA, IHC-P, FCM, ICC/IF, IF, IP.
PARK7 / DJ-1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each PARK7 / DJ-1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). DJ-1/p53 interactions contribute to apoptosis resistance in clonal myeloid cells and may serve as a prognostic marker in patients with myelodysplastic syndromes (MDS). DJ-1 regulates redox signaling kinase pathways and acts as a transcriptional regulator of antioxidative gene batteries. Therefore, DJ-1 is an important redox-reactive signaling intermediate controlling oxidative stress after ischemia, upon neuroinflammation, and during age-related neurodegenerative processes. Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke.