PARK7 / DJ-1 Protein

Parkinson Disease (autosomal recessive, early onset) 7

PARK7 / DJ-1 Products

PARK7 / DJ-1 Protein, Recombinant

Molecule	Species	Description	Cat. No
PARK7/DJ-1	Human	PARK7/DJ-1 Protein, Recombinant	12484-H08E

PARK7 / DJ-1 Antibody

Molecule	Application	Description	Cat. No
Human PARK7 / DJ-1	WB, ELISA	PARK7 / DJ-1 Antibody (Antigen Affinity Purified)	12484-RP02

PARK7 / DJ-1 Related Areas

Cancer>>Apoptosis>>Oxidative Stress>>PARK7/DJ-1

Neuroscience>>Neurodegeneration>>Parkinson's Disease>>PARK7/DJ-1

PARK7 / DJ-1 Alternative Names

PARK7, DJ-1, CTA-215D11.1, DJ1, FLJ27376, FLJ34360, FLJ92274 [Homo sapiens]

Park7, DJ-1, RP23-272N19.5, Dj1 [Mus musculus]

PARK7 / DJ-1 Background

Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). DJ-1/p53 interactions contribute to apoptosis resistance in clonal myeloid cells and may serve as a prognostic marker in patients with myelodysplastic syndromes (MDS). DJ-1 regulates redox signaling kinase pathways and acts as a transcriptional regulator of antioxidative gene batteries. Therefore, DJ-1 is an important redox-reactive signaling intermediate controlling oxidative stress after ischemia, upon neuroinflammation, and during age-related neurodegenerative processes. Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke.

PARK7 / DJ-1 Related Studies

1. Takahashi K, et al. (2001). DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J. Biol. Chem. (United States). 276 (40): 37556-63.
2. Niki, Takeshi, et al. (2003). DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Mol. Cancer Res. (United States). 1 (4): 247-61.
3. Kahle PJ, et al. (2009) DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. Free Radic Biol Med. 47(10): 1354-61.
4. Xu X, et al. (2010) The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage. Blood Cells Mol Dis. 45(3): 227-32.
5. Marcondes AM, et al. (2010) Identification of DJ-1/PARK-7 as a determinant of stroma-dependent and TNF-alpha-induced apoptosis in MDS using mass spectrometry and phosphopeptide analysis. Blood. 115(10): 1993-2002.