Anti-PARK7 / DJ-1 Antibody (Rabbit Polyclonal antibody) General Information
Anti-PARK7 / DJ-1 Antibody
Reacts with: Human
Human PARK7 / DJ-1
Recombinant Human PARK7 / DJ-1 protein (Catalog#12484-H08E)
Produced in rabbits immunized with purified, recombinant Human PARK7 / DJ-1 (rh PARK7 / DJ-1; Catalog#12484-H08E; Q99497-1; Met 1-Asp 189). PARK7 / DJ-1 specific IgG was purified by Human PARK7 / DJ-1 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PARK7 / DJ-1 Antibody (Rabbit Polyclonal antibody) Validated Applications
|| 0.1-0.2 μg/mL
|| 0.05-1 μg/mL
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-PARK7 / DJ-1 Antibody (Rabbit Polyclonal antibody) Images
Immunochemical staining of human PARK7 in human thyroid gland with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections).
Immunochemical staining of human PARK7 in human brain with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections).
Anti-PARK7 / DJ-1 Antibody Alternative Names
Anti-DJ-1 Antibody;Anti-DJ1 Antibody;Anti-HEL-S-67p Antibody
PARK7 / DJ-1 Background Information
Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). DJ-1/p53 interactions contribute to apoptosis resistance in clonal myeloid cells and may serve as a prognostic marker in patients with myelodysplastic syndromes (MDS). DJ-1 regulates redox signaling kinase pathways and acts as a transcriptional regulator of antioxidative gene batteries. Therefore, DJ-1 is an important redox-reactive signaling intermediate controlling oxidative stress after ischemia, upon neuroinflammation, and during age-related neurodegenerative processes. Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke.
parkinson protein 7
Takahashi K, et al. (2001). DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J. Biol. Chem. (United States). 276 (40): 37556-63.Niki, Takeshi, et al. (2003). DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Mol. Cancer Res. (United States). 1 (4): 247-61.Kahle PJ, et al. (2009) DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. Free Radic Biol Med. 47(10): 1354-61.Xu X, et al. (2010) The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage. Blood Cells Mol Dis. 45(3): 227-32.Marcondes AM, et al. (2010) Identification of DJ-1/PARK-7 as a determinant of stroma-dependent and TNF-alpha-induced apoptosis in MDS using mass spectrometry and phosphopeptide analysis. Blood. 115(10): 1993-2002.