Anti-PARK7 / DJ-1 Antibody

Cat: 12484-RP02
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Anti-PARK7 / DJ-1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-PARK7 / DJ-1 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human PARK7 / DJ-1
Immunogen
Recombinant Human PARK7 / DJ-1 protein (Catalog#12484-H08E)
Preparation
Produced in rabbits immunized with purified, recombinant Human PARK7 / DJ-1 (rh PARK7 / DJ-1; Catalog#12484-H08E; Q99497-1; Met 1-Asp 189). PARK7 / DJ-1 specific IgG was purified by Human PARK7 / DJ-1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-PARK7 / DJ-1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 0.1-0.2 μg/mL  
IHC-P 0.05-1 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-PARK7 / DJ-1 Antibody (Rabbit Polyclonal antibody) Images
Human PARK7/DJ-1 Immunohistochemistry(IHC) 3819
Immunochemical staining of human PARK7 in human thyroid gland with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections).
Human PARK7/DJ-1 Immunohistochemistry(IHC) 3821
Immunochemical staining of human PARK7 in human brain with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections).
Anti-PARK7 / DJ-1 Antibody Alternative Names
Anti-DJ-1 Antibody;Anti-DJ1 Antibody;Anti-HEL-S-67p Antibody
PARK7 / DJ-1 Background Information

Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). DJ-1/p53 interactions contribute to apoptosis resistance in clonal myeloid cells and may serve as a prognostic marker in patients with myelodysplastic syndromes (MDS). DJ-1 regulates redox signaling kinase pathways and acts as a transcriptional regulator of antioxidative gene batteries. Therefore, DJ-1 is an important redox-reactive signaling intermediate controlling oxidative stress after ischemia, upon neuroinflammation, and during age-related neurodegenerative processes. Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke.

Full Name
parkinson protein 7
References
  • Takahashi K, et al. (2001). DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J. Biol. Chem. (United States). 276 (40): 37556-63.
  • Niki, Takeshi, et al. (2003). DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Mol. Cancer Res. (United States). 1 (4): 247-61.
  • Kahle PJ, et al. (2009) DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. Free Radic Biol Med. 47(10): 1354-61.
  • Xu X, et al. (2010) The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage. Blood Cells Mol Dis. 45(3): 227-32.
  • Marcondes AM, et al. (2010) Identification of DJ-1/PARK-7 as a determinant of stroma-dependent and TNF-alpha-induced apoptosis in MDS using mass spectrometry and phosphopeptide analysis. Blood. 115(10): 1993-2002.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-PARK7 / DJ-1 Antibody Rabbit Monoclonal WB,FCM,ICC/IF,IF,IP 12484-R007
    Anti-PARK7 / DJ-1 Antibody Rabbit Polyclonal WB 12484-RP01
    Anti-PARK7 / DJ-1 Antibody Rabbit Polyclonal WB,ELISA,IHC-P 12484-T56
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