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> PAPPA2 PAPPA2
PAPPA2 is metalloproteinase which specifically cleaves IGFBP-5. PAPPA2 shows limited proteolysis toward IGFBP-3.
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PAPPA2 Related Areas
Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>PAPPA2
PAPPA2 Related Pathways
PAPPA2 Alternative Names
PAPPA2, PAPP-A2, pappalysin 2, PLAC3, PAPPE, RP4-774I24.1 [Homo sapiens]
PAPPA2, PAPP-A2, pappalysin 2, PLAC3, Pappe [Mus musculus]
Summaries for PAPPA2
Entrez Gene summary for PAPPA2:
This PAPPA2 gene encodes a member of the pappalysin family of metzincin metalloproteinases. PAPPA2 cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Wikipedia summary for PAPPA2:
Pappalysin-2 is a protein that in humans is encoded by the PAPPA2 gene
Human PAPPA2 Protein General Information
| Protein names |
Pappalysin-2 |
| Sequence length |
1791 AA. |
| Catalytic activity |
Cleavage of the 143-Ser-|-Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5. |
| Sequence similarities: |
PAPPA2 belongs to the peptidase M43B family. PAPPA2 contains 5 Sushi (CCP/SCR) domains. |
| Cofactor: |
PAPPA2 binds 1 zinc ion per subunit |
| Subunit structure |
Monomer. |
| Subcellular location: | Secreted |
| Tissue specificity |
PAPPA2 is expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas. |
| Sequence caution: | The sequence AAL17779.1 differs from that shown. Reason: Erroneous initiation. The sequence AAL17780.1 differs from that shown. Reason: Erroneous initiation. The sequence CAC11134.1 differs from that shown. Reason: Erroneous initiation. |
General information above from UniProt
Function for PAPPA2 Protein
UniProtKB:
PAPPA2 is metalloproteinase which specifically cleaves IGFBP-5. PAPPA2 shows limited proteolysis toward IGFBP-3.
Genatlas:
- PAPPA2 is involved in placenta development and foetus maternal interface
- PAPPA2 may have insulin-like growth factor-binding protein-5 proteinase activity
- PAPPA2 is protease that cleaves IGF-binding proteins (Winn 2009)
- PAPPA2 may be up-regulated in pre-eclamptic pregnancy to compensate for IGFBP5-mediated suppression of the IGF pathway, although final birthweights are still low in pre-eclamptic pregnancy (Nishizawa 2008)
