PAI-1 (Protein|Antibody|cDNA Clone|ELISA Kit)

All PAI-1 reagents are produced in house and quality controlled, including 8 PAI-1 Antibody, 2 PAI-1 ELISA, 29 PAI-1 Gene, 3 PAI-1 Lysate, 3 PAI-1 Protein, 2 PAI-1 qPCR. All PAI-1 reagents are ready to use.

Recombinant PAI-1 proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc.

PAI-1antibodies are validated with different applications, which are ELISA, ELISA(Det), ELISA(Cap), WB.

PAI-1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each PAI-1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

PAI-1ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.

PAI-1 Protein (3)

Species

PAI-1 Protein, Rat, Recombinant (His Tag)

80442-R08H

Expression host: HEK293 Cells

Rat PAI-1 / SerpinE1 Protein 12642

PAI-1 Protein, Human, Recombinant (His Tag)

10296-H08H

Expression host: HEK293 Cells

Human PAI-1 / SerpinE1 Protein 8640

PAI-1 Protein, Rat, Recombinant (Fc Tag)

80442-R02H

Expression host: HEK293 Cells

Rat PAI-1 / SerpinE1 Protein 12641
Go

PAI-1 Antibody (8)

Application Clonality
Host

Anti-PAI-1 Antibody

10296-RP01

Application: WB,ELISA

Clonality: PAb

Human PAI-1 / SerpinE1 Western blot (WB) 13172

Anti-PAI-1 Antibody

10296-RP02

Application: ELISA

Clonality: PAb

Anti-PAI-1 Antibody

10296-R004

Application: ELISA,ELISA(Det)

Clonality: MAb

Anti-PAI-1 Antibody

10296-T16

Application: ELISA

Clonality: PAb

Anti-PAI-1 Antibody

10296-MM01

Application: ELISA(Cap)

Clonality: MAb

Anti-PAI-1 Antibody

80442-T16

Application: ELISA

Clonality: PAb

Anti-PAI-1 Antibody

80442-R001

Application: ELISA

Clonality: MAb

Anti-PAI-1 Antibody

80442-RP01

Application: ELISA

Clonality: PAb

Go

PAI-1 ELISA KIT & match antibody elias pair set ( 2 )

PAI-1 Matched ELISA Antibody Pair Set,Human

SEK10296

Assay Range: 46.88 pg/ml

Human PAI-1 / SerpinE1 ELISA Pair Set Standard Curve 17737

PAI-1 ELISA Kit, Human

KIT10296

Sensitivity: 5.84 pg/mL

Human PAI-1 / SerpinE1 ELISA Kit Standard Curve 56

PAI-1 cDNA Clone (29)

Human
Rat
Mouse

PAI-1 qPCR Primer (2)

PAI-1 Lysate (3)

Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein which belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Defects in SerpinE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SerpinE1 defect in the plasma. High concentrations of SerpinE1 have been associated with thrombophilia which is an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis. Studies of PAI-1 have contributed significantly to the elucidation of the protease inhibitory mechanism of serpins, which is based on a metastable native state becoming stabilised by insertion of the RCL into the central beta-sheet A and formation of covalent complexes with target proteases. Greater expression of PAI-1 has been associated with increased survival of cells and resistance to apoptosis. PAI-1 appears to influence apoptosis by decreasing cell adhesion (anoikis) as well as its effect on intracellular signaling. PAI-1, in its active state, also binds to the extracellular protein vitronectin. When in complex with its target proteases, it binds with high affinity to endocytosis receptors of the low density receptor family. The mechanisms of PAI-1 overexpression during obesity are complex, and it is conceivable that several inducers are involved at the same time at several sites of synthesis. PAI-1 is also implicated in adipose tissue development. It suggests that PAI-1 inhibitors serve in the control of atherothrombosis.

Protein
Antibody
ELISA
Gene
qPCR
Lysate
Close