P38 alpha / MAPK14 Protein

Mitogen-Activated Protein Kinase 14

P38 alpha / MAPK14 Products

P38 alpha / MAPK14 Protein, Recombinant

Molecule	Species	Description	Cat. No
p38 alpha/MAPK14	Human	p38 alpha/MAPK14 Protein, Recombinant	10081-H08B
p38 alpha/MAPK14	Human	p38 alpha/MAPK14 Protein, Recombinant	10646-H07B
p38 alpha/MAPK14	Human	p38 alpha/MAPK148 Protein, Recombinant	10646-HNCB

P38 alpha / MAPK14 cDNA Clone

Molecule	Species	Description	Cat. No
p38 alpha/MAPK14	Human	Homo sapiens p38 alpha/MAPK14 cDNA Clone(NM_139012.1)	HG10081-M
p38 alpha/MAPK14	Human	Homo sapiens p38 alpha/MAPK14 cDNA Clone(NM_001315.2)	HG10646-M
p38 alpha/MAPK14	Mouse	Mouse p38 alpha/MAPK14 cDNA Clone / ORF Clone	MG50825-G

P38 alpha / MAPK14 Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>p38 alpha/MAPK14

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>p38 alpha/MAPK14

P38 alpha / MAPK14 Alternative Names

p38ALPHA, MAPK14, p38, CSBP1, CSBP2, Mxi2, PRKM14, PRKM15, RK, CSPB1, SAPK2A, EXIP, RP1-179N16.5 [Homo sapiens]

p38-alpha, Mapk14, p38, p38MAPK, p38a, p38alpha, Csbp1, CSBP2, Mxi2, PRKM14, PRKM15, Crk1, MGC102436, RP24-137E7.1 [Mus musculus]

P38 alpha / MAPK14 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
ERK2/MAPK1/MAPK2	Human	ERK2/MAPK1 Protein, Recombinant, With GST Tag
JNK1/MAPK8	Human	JNK1/MAPK8 Protein, Recombinant
JNK2/MAPK9	Human	JNK2/MAPK9 Protein, Recombinant
p38 delta/MAPK13	Human	p38 delta/MAPK13 Protein, Recombinant, with GST Tag
MAPKAPK3	Human	MAPKAPK3 Protein, Recombinant

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
ERK2/MAPK1/MAPK2	Human	Homo sapiens ERK2 transcript variant 1 cDNA Clone(NM_002745.4)
ERK3/MAPK6	Human	Homo sapiens ERK3 cDNA Clone(NM_002748.2)
ERK5/BMK1/MAPK7	Human	Homo sapiens ERK5/BMK1 transcript variant 3 cDNA Clone(NM_002749.2)
JNK1/MAPK8	Human	Homo sapiens JNK1/MAPK8 cDNA Clone(NM_139047.1)
JNK1/MAPK8	Mouse	Mus musculus JNK1/MAPK8 cDNA Clone
JNK2/MAPK9	Human	Homo sapiens JNK2/MAPK9 cDNA Clone(NM_002752.4)
p38 delta/MAPK13	Human	Homo sapiens p38 delta/MAPK13 cDNA Clone(NM_002754.3)
MEK2/MKK2/MAP2K2	Human	Homo sapiens MEK2/MKK2/MAP2K2 cDNA Clone(NM_030662.3)
MKK6/MEK6/MAP2K6	Human	Homo sapiens MKK6/MEK6/MAP2K6 cDNA Clone(NM_002758.3)
MEKK3/MAP3K3/MAPKKK3	Human	Homo sapiens MEKK3/MAP3K3 cDNA Clone(NM_002401.3)
TPL2/MAP3K8/MEKK8	Human	Homo sapiens TPL2/MAP3K8 cDNA Clone(NM_005204.2)
MAPKAPK3	Human	Homo sapiens MAPKAPK3 cDNA Clone(NM_004635.3)
MNK1/MKNK1	Human	Homo sapiens MNK1/MKNK1 transcript variant 2 cDNA Clone(NM_001135553.1)
MNK1/MKNK1	Human	Homo sapiens MNK1/MKNK1 transcript variant 3 cDNA Clone(NM_198973.2)

P38 alpha / MAPK14 Background

MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK14 can be detected in brain, heart, placenta, pancreas and skeletal muscle and it is expressed to a lesser extent in lung, liver and kidney. MAPK14 is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with MAPK14. The substrates of p38 alpha include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of p38 alpha in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. In respond to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide, MAPK14 phosphorylates a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. MAPK14 plays a critical role in the production of some cytokines, for example IL-6. It may play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2.

P38 alpha / MAPK14 Related Studies

1. Luo X, et al. (2011) Study on p38 mitogen activated protein kinase in vascular endothelial cells dysfunction in preeclampsia. Zhonghua Fu Chan Ke Za Zhi. 46(1):36-40.
2. Park CH, et al. (2011) Epidermal growth factor-induced matrix metalloproteinase-1 expression is negatively regulated by p38 MAPK in human skin fibroblasts. J Dermatol Sci. 64(2):134-41.
3. Lee JY, et al. (2011) Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy. PLoS One. 6(8):e23756.
4. Riis JL, et al. (2011) CCL27 expression is regulated by both p38 MAPK and IKKβ signalling pathways. Cytokine. 56(3):699-707.