P-Selectin

P selectin (SELP) is a 140kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. SELP mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P selectin is a cell adhesion molecule on the surface of activated endothelial cells. Cellular adhesion molecules are a large family of proteins that attach the cytoskeleton and intracellular signaling cascades with the extracellular environment. SELP is a calcium-dependent receptor for myeloid cells that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interacton of activated endothelial cells or platelets with leukocytes.

P-Selectin Related Areas

Immunology>>Adaptive Immunity >>T Cell >>T Cell Migration/Adhesion >> SELP/ P selectin

P-Selectin Alternative Names

RP1-86F14.2, CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL[Homo sapiens]

CD62 antigen-like family member P; GMP-140; LECAM3; P-selectin; PADGEM; granule membrane protein 140; leukocyte-endothelial cell adhesion molecule 3; platelet activation dependent granule-external membrane protein [Mus musculus]

Summaries for P-Selectin

Entrez Gene summary for P-Selectin:

SELP gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.

Wikipedia summary for P-Selectin:

P-selectin is a protein that in humans is encoded by the SELP gene.
P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies, and α-granules in unactivated platelets.
Other names for P-selectin include CD62P, Granule Membrane Protein 140 (GMP-140), and Platelet Activation-Dependent Granule to External Membrane Protein (PADGEM). It was first identified in endothelial cells in 1989.

Human P-Selectin Protein General Information

 

• Protein names: P-Selectin
• Sequence length: 830 AA.
• Domain: EGF-like domain; Repeat; Signal; Sushi; Transmembrane; Transmembrane helix
• Sequence similarities: Belongs to the selectin/LECAM family.
  Contains 1 C-type lectin domain.
  Contains 1 EGF-like domain.
  Contains 9 Sushi (CCP/SCR) domains.
• Subunit structure: Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.
• Subcellular location: Membrane; Single-pass type I membrane protein.
• Tissue specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
• Involvement in disease: Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) ; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.

General information above from UniProt

Function for P-Selectin Protein

UniProtKB:

P-Selectin is Ca²⁺-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. P-Selectin mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. P-Selectin mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

Genatlas:

• P-Selectin mediates interaction of leukocytes with blood vessel wall

Phenotype Information for P-Selectin

• Gene/Locus: SELP, GRMP
• Phenotype: Platelet alpha/delta storage pool deficiency
  Atopy, susceptibility to}

Phenotype Information for P-Selectin from OMIM (Online Mendelian Inheritance in Man)