Osteoprotegerin cDNA ORF Clone in Cloning Vector, Human

Cat: HG10271-M
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Osteoprotegerin cDNA ORF Clone in Cloning Vector, Human General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
1206 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for a point mutation 888T/C not resulting in amino acid variation.
Description
Full length Clone DNA of Human tumor necrosis factor receptor superfamily, member 11b.
Plasmid
Vector
pMD18-T Simple Vector
Sequencing Primers
M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
Osteoprotegerin cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Osteoprotegerin cDNA ORF Clone in Cloning Vector, Human Alternative Names
MGC29565 cDNA ORF Clone, Human;OCIF cDNA ORF Clone, Human;OPG cDNA ORF Clone, Human;PDB5 cDNA ORF Clone, Human;TR1 cDNA ORF Clone, Human
Osteoprotegerin Background Information

Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.

Full Name
tumor necrosis factor receptor superfamily member 11b
References
  • Collin-Osdoby P. (2005) Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res. 95 (11): 1046-57.
  • Boyce BF, et al. (2007) Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res. Ther. 9 Suppl 1: S1.
  • Blázquez-Medela AM, et al. ( 2011) Osteoprotegerin and diabetes-associated pathologies. Curr Mol Med. 11 (5): 401-16.
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    Product Name Catalog#(PDF)
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    Osteoprotegerin Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10271-ACGLN
    Osteoprotegerin cDNA ORF Clone, Human, C-OFPSpark® tag HG10271-ACR
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    Osteoprotegerin cDNA ORF Clone, Human, C-His tag HG10271-CH
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    Osteoprotegerin cDNA ORF Clone, Human, N-Myc tag HG10271-NM
    Osteoprotegerin qPCR Primer Pairs, Human HP100319
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