Osteoprotegerin / TNFRSF11B Protein

Tumor Necrosis Factor Receptor Superfamily, member 11b

Osteoprotegerin / TNFRSF11B Products

Osteoprotegerin / TNFRSF11B Protein, Recombinant

Molecule	Species	Description	Cat. No
Osteoprotegerin/TNFRSF11B	Human	Osteoprotegerin/TNFRSF11B Protein, Recombinant	10271-H08H

Osteoprotegerin / TNFRSF11B cDNA Clone

Molecule	Species	Description	Cat. No
Osteoprotegerin/TNFRSF11B	Human	Homo sapiens Osteoprotegerin/TNFRSF11 cDNA Clone	HG10271-M

Osteoprotegerin / TNFRSF11B Related Areas

Immunology>>Cytokine & Receptor>>TNF Superfamily>>Osteoprotegerin/TNFRSF11B

Osteoprotegerin / TNFRSF11B Alternative Names

Osteoprotegerin, TNFRSF11B, MGC29565, OCIF, OPG, TR1 [Homo sapiens]

Osteoprotegerin, Tnfrsf11b, OCIF, Opg, TR1 [Mus musculus]

Osteoprotegerin / TNFRSF11B Background

Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.

Osteoprotegerin / TNFRSF11B Related Studies

1. Collin-Osdoby P. (2005) Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res. 95 (11): 1046-57.
2. Boyce BF, et al. (2007) Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res. Ther. 9 Suppl 1: S1.
3. Blázquez-Medela AM, et al. ( 2011) Osteoprotegerin and diabetes-associated pathologies. Curr Mol Med. 11 (5): 401-16.