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Osteoprotegerin/TNFRSF11B Protein, Antibody, ELISA Kit, cDNA Clone

Osteoprotegerin/TNFRSF11B Related Areas

Osteoprotegerin/TNFRSF11B Related Pathways

Osteoprotegerin/TNFRSF11B Related Product

Osteoprotegerin/TNFRSF11B Summary & Protein Information

Osteoprotegerin/TNFRSF11B Related Information

Osteoprotegerin/TNFRSF11B Background

Gene Summary: Osteoprotegerin, the protein encoded by this TNFRSF11B gene is a member of the TNF-receptor superfamily. Osteoprotegerin is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. Osteoprotegerin specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this TNFRSF11B gene have been reported, but their full length nature has not been determined.
General information above from NCBI
Subunit structure: Homodimer. Interacts with TNFSF10 and TNFSF11.
Subcellular location: Secreted.
Tissue specificity: Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
Induction: Up-regulated by increasing calcium-concentration in the medium and estrogens. Down-regulated by glucocorticoids.
Post-translational: N-glycosylated. Contains sialic acid residues.
The N-terminus is blocked.
Involvement in disease: Juvenile Paget disease (JPD) [MIM:239000]: Rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast- mediated skeletal resorption, the disease can be fatal. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Contains 2 death domains.
Contains 4 TNFR-Cys repeats.
General information above from UniProt

Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.

Osteoprotegerin/TNFRSF11B Alternative Name

Osteoprotegerin,TNFRSF11B,TR1,MGC29565,OCIF,OPG, [human]
Osteoprotegerin,Tnfrsf11b,TR1,OPG,OCIF, [mouse]

Osteoprotegerin/TNFRSF11B Related Studies

  • Collin-Osdoby P. (2005) Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res. 95 (11): 1046-57.
  • Boyce BF, et al. (2007) Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res. Ther. 9 Suppl 1: S1.
  • Blázquez-Medela AM, et al. ( 2011) Osteoprotegerin and diabetes-associated pathologies. Curr Mol Med. 11 (5): 401-16.
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