Osteoprotegerin / TNFRSF11B Protein & Antibody
Tumor Necrosis Factor Receptor Superfamily, member 11b
Osteoprotegerin / TNFRSF11B Products
Osteoprotegerin / TNFRSF11B Protein, Recombinant
Osteoprotegerin / TNFRSF11B Antibody
Osteoprotegerin / TNFRSF11B cDNA Clone
Osteoprotegerin / TNFRSF11B Related Areas
Immunology>>Cytokine & Receptor>>TNF Superfamily>>Osteoprotegerin/TNFRSF11B
Osteoprotegerin / TNFRSF11B Alternative Names
Osteoprotegerin, TNFRSF11B, MGC29565, OCIF, OPG, TR1 [Homo sapiens]
Osteoprotegerin, Tnfrsf11b, OCIF, Opg, TR1 [Mus musculus]
Osteoprotegerin / TNFRSF11B Background
Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
Osteoprotegerin / TNFRSF11B Related Studies
- Collin-Osdoby P. (2005) Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res. 95 (11): 1046-57.
- Boyce BF, et al. (2007) Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res. Ther. 9 Suppl 1: S1.
- Blázquez-Medela AM, et al. ( 2011) Osteoprotegerin and diabetes-associated pathologies. Curr Mol Med. 11 (5): 401-16.
TNF Superfamily Ligands
TNF Receptor Superfamily