All Osteoprotegerin reagents are produced in house and quality controlled, including 3 Osteoprotegerin Antibody, 39 Osteoprotegerin Gene, 3 Osteoprotegerin Lysate, 3 Osteoprotegerin Protein, 3 Osteoprotegerin qPCR. All Osteoprotegerin reagents are ready to use.
Recombinant Osteoprotegerin proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
Osteoprotegerinantibodies are validated with different applications, which are ELISA.
OsteoprotegerincDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Osteoprotegerin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.