Osteoprotegerin / TNFRSF11B Protein & Antibody

Tumor Necrosis Factor Receptor Superfamily, member 11b

Osteoprotegerin / TNFRSF11B Products

Osteoprotegerin / TNFRSF11B Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Osteoprotegerin/TNFRSF11B	Human	Osteoprotegerin/TNFRSF11B Protein, Recombinant	10271-H08H

Osteoprotegerin / TNFRSF11B Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Osteoprotegerin/TNFRSF11B	ELISA	Osteoprotegerin / TNFRSF11B Antibody	10271-R340

Osteoprotegerin / TNFRSF11B cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Osteoprotegerin/TNFRSF11B	Human	Homo sapiens Osteoprotegerin/TNFRSF11 cDNA Clone	HG10271-M

Osteoprotegerin / TNFRSF11B Related Areas

Immunology>>Cytokine & Receptor>>TNF Superfamily>>Osteoprotegerin/TNFRSF11B

Osteoprotegerin / TNFRSF11B Alternative Names

Osteoprotegerin, TNFRSF11B, MGC29565, OCIF, OPG, TR1 [Homo sapiens]

Osteoprotegerin, Tnfrsf11b, OCIF, Opg, TR1 [Mus musculus]

Osteoprotegerin / TNFRSF11B Background

Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.

Osteoprotegerin / TNFRSF11B Related Studies

Collin-Osdoby P. (2005) Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res. 95 (11): 1046-57.
Boyce BF, et al. (2007) Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res. Ther. 9 Suppl 1: S1.
Blázquez-Medela AM, et al. ( 2011) Osteoprotegerin and diabetes-associated pathologies. Curr Mol Med. 11 (5): 401-16.

TNF Superfamily Ligands

EDA-A1 / Ectodysplasin-A1^*	TNFSF5 / CD40L / CD154	TNFSF11 / RANKL / OPGL
TNF-alpha / TNFSF2	TNFSF6 / CD95L / CD178^*	TNFSF12 / TWEAK^*
TNF-beta / TNFSF1 / Lymphotoxin alpha	TNFSF7 / CD70 / CD27L	TNFSF13 / CD256^*
TNFSF3 / TNFC / lymphotoxin beta^*	TNFSF8 / CD153 / CD30L	TNFSF13B / BlyS / CD257
TNFSF3L / PGLYRP1 / PGRP-S	TNFSF9 / 4-1BBL / CD137L	TNFSF14 / LIGHT / CD258
TNFSF4^*	TNFSF10 / CD253 / TRAIL	TNFSF15^*

TNF Receptor Superfamily

EDAR	TNFRSF9 / CD137 / 4-1BB	TNFRSF14 / HVEM
TNFRSF1A / TNFR1 / CD120a	TNFRSF10A / CD261 / TRAILR1	TNFRSF16 / NGFR / P75
TNFRSF1B / TNFR2 / CD120b	TNFRSF10B / CD262 / TRAILR2	TNFRSF17 / BCMA / CD269
TNFRSF3 / CD18 / LTBR^*	TNFRSF10C / CD263 / TRAILR3^*	TNFRSF18^*
TNFRSF4 / OX40 / CD134	TNFRSF10D / CD264 / TRAILR4	TNFRSF19 / TROY
TNFRSF5 / CD40	TNFRSF11A	TNFRSF19L / RELT
TNFRSF6 / CD95 / APO-1	TNFRSF11B / Osteoprotegerin	TNFRSF21 / DR6
TNFRSF6B / DcR3	TNFRSF12A / FN14 / TWEAKR^*	TNFRSF25 / DR3 / TNFRSF12
TNFRSF7 / CD27	TNFRSF13B / TACI	TNFRSF27 / XEDAR / EDA2R
TNFRSF8 / CD30	TNFRSF13C / BAFFR