Osteopontin Protein & Antibody (SPP1, ETA-1)

Secreted Phosphoprotein 1 / Early T-lymphocyte Activation 1

Osteopontin Protein Products

Osteopontin Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Osteopontin/SPP1/ETA-1	Human	Osteopontin/SPP1/ETA-1 Protein, Recombinant	10352-H08H

Osteopontin Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Osteopontin/SPP1/ETA-1	WB, ELISA	Rabbit Polyclonal Antibody	10352-RP01
Human Osteopontin/SPP1/ETA-1	WB, ELISA	Osteopontin/SPP1/ETA-1 Antibody, Rabbit PAb (Antigen Affinity Purified)	10352-RP02
Human Osteopontin/SPP1/ETA-1	ELISA, FCM	Osteopontin / SPP1 / ETA-1 Antibody	10352-R001
Human Osteopontin/SPP1/ETA-1	WB, ELISA	Osteopontin / SPP1 / ETA-1 Antibody	10352-R014

Osteopontin cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Osteopontin/SPP1/ETA-1	Human	Homo sapiens Osteopontin/SPP1/ETA-1 transcript variant 1 cDNA Clone(NM_001040058.1)	HG10352-M
Osteopontin/SPP1/ETA-1	Mouse	Mus musculus Osteopontin/SPP1/ETA-1 cDNA Clone	MG50116-M

Osteopontin Related Areas

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>Osteopontin/SPP1/ETA-1

Cancer>>Cancer Biomarkers>>Osteopontin/SPP1/ETA-1

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker>>Osteopontin/SPP1/ETA-1

Osteopontin Alternative Names

Osteopontin, SPP1, ETA-1, OPN, BNSP, BSPI, MGC110940 [Homo sapiens]

Osteopontin, Spp1, Spp-1, ETA-1, Eta, Opn, OP, Opnl, BNSP, BSPI, Bsp, AA960535, AI790405, Apl-1, Ric [Mus musculus]

Osteopontin Background

Osteopontin, also known as Secreted phosphoprotein 1, Bone sialoprotein 1, BSP-1, OPN, and SPP1, is a member of the osteopontin family and a SIBLING glycoprotein. Osteopontin has been classified as T-helper 1 cytokine and thus believed to exacerbate inflammation in several chronic inflammatory diseases, including atherosclerosis. Besides proinflammatory functions, physiologically Osteopontin is a potent inhibitor of mineralization, it prevents ectopic calcium deposits and is a potent inducible inhibitor of vascular calcification. Osteopontin is expressed and secreted by various cells, and has a role in cell adhesion, chemotaxis, prevention of apoptosis, invasion, migration and anchorage-independent growth of tumor cells. Osteopontin recruitment functions of inflammatory cells are thought to be mediated through its adhesive domains, especially the arginine-glycine-aspartate (RGD) sequence that interacts with several integrin heterodimers. Osteopontin has emerged as a potential biomarker and mediator in cardiovascular disease. In the context of atherosclerosis, OPN is generally regarded as a proinflammatory and proatherogenic molecule. However, the role of OPN in vascular calcification (VC), which is closely related to chronic and active inflammation, is that of a negative regulator because it is an inhibitor of calcification and an active inducer of decalcification. Extensive research has demonstrated the pivotal participation of Osteopontin in the regulation of cell signaling which controls neoplastic and malignant transformation. The elevated expression of Osteopontin has been observed in a variety of cancers. It has been linked with tumor metastasis and signifies a poor prognosis for the patient.

Osteopontin Related Studies

1. Scatena M, et al. (2007) Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol. 27(11): 2302-9.
2. Johnston NI, et al. (2008) Osteopontin as a target for cancer therapy. Front Biosci. 13: 4361-72.
3. Cho HJ, et al. (2009) Osteopontin: a multifunctional protein at the crossroads of inflammation, atherosclerosis, and vascular calcification. Curr Atheroscler Rep. 11(3): 206-13.
4. Waller AH, et al. (2010) Osteopontin in cardiovascular disease: a potential therapeutic target. Cardiol Rev. 18(3): 125-31.
5. Shevde LA, et al. (2010) Osteopontin: an effector and an effect of tumor metastasis. Curr Mol Med. 10(1): 71-81.