Osteomodulin Protein & Antibody

Osteomodulin Products

Osteomodulin Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
Osteomodulin	Mouse	Osteomodulin/OMD Protein, Recombinant	50451-M08H

Osteomodulin Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat No
Mouse Osteomodulin	WB, ELISA	Osteomodulin Antibody, Rabbit PAb	50451-RP01
Mouse Osteomodulin	WB, ELISA	Osteomodulin Antibody, Rabbit PAb (Antigen Affinity Purified)	50451-RP02

Osteomodulin cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
Osteomodulin	Human	Homo sapiens Osteomodulin/OMD cDNA Clone	HG10825-M
Osteomodulin	Mouse	Mus musculus Osteomodulin/OMD cDNA Clone	MG50451-M

Osteomodulin Related Areas

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Proteoglycan>>Osteomodulin

Osteomodulin Alternative Names

Osteomodulin, OMD, osteoadherin, OSAD, SLRR2C, UNQ190/PRO216 [Homo sapiens]

Osteomodulin, Omd, osteoadherin, OSAD, SLRR2C [Mus musculus]

Osteomodulin Background

Osteomodulin (OMD), also known as Osteoadherin (OSAD), Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, and SLRR2C, is a secreted protein which belongs to the small leucine-rich proteoglycan (SLRP) family and Class II subfamily. SLRP family proteins are normally found in extracellular matrices, but Osteomodulin is the only member restricted to mineralized tissues. Osteomodulin is primarily expressed by osteoblasts and might have a role in regulation of mineralization. In bone OSAD has been localized in primary spongiosa within the bovine fetal rib growth plate. Moreover, in situ hybridization has shown expression of OSAD in osteoblasts close to the cartilage and bone border in the growth plate of rat femur. OSAD may play an important role during tooth development and biomineralization of dentin. Osteomodulin is a cell binding keratan sulfate proteoglycan which was recently isolated from mineralized bovine bone and subsequently cloned and sequenced. Osteomodulin may be implicated in biomineralization processes. It has a function in binding of osteoblasts via the alpha (V) beta (3)-integrin. It is likely that Osteomodulin is an osteoblast maturation marker that is induced by osteoclast activity. Osteomodulin is also an early marker for terminally differentiated matrix producing osteoblasts.

Osteomodulin# Related Studies

1. Buchaille R, et al. (2000) Expression of the small leucine-rich proteoglycan osteoadherin/osteomodulin in human dental pulp and developing rat teeth. Bone. 27(2): 265-70.
2. Petersson U, et al. (2003) Identification, distribution and expression of osteoadherin during tooth formation. Eur J Oral Sci. 111(2): 128-36.
3. Rehn AP, et al. (2006) Differential regulation of osteoadherin (OSAD) by TGF-beta1 and BMP-2. Biochem Biophys Res Commun. 349(3): 1057-64.