Anti-OMD Antibody

Cat: 50451-RP01
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Anti-OMD Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-OMD Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse OMD
Immunogen
Recombinant Mouse OMD protein (Catalog#50451-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse OMD (rM OMD; Catalog#50451-M08H; NP_036180.1; Met 1-Ile 423). Total IgG was purified by Protein A affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-OMD Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-OMD Antibody Alternative Names
Anti-OSAD Antibody;Anti-SLRR2C Antibody
OMD Background Information

Osteomodulin (OMD), also known as Osteoadherin (OSAD), Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, and SLRR2C, is a secreted protein which belongs to the small leucine-rich proteoglycan (SLRP) family and Class II subfamily. SLRP family proteins are normally found in extracellular matrices, but Osteomodulin is the only member restricted to mineralized tissues. Osteomodulin is primarily expressed by osteoblasts and might have a role in regulation of mineralization. In bone OSAD has been localized in primary spongiosa within the bovine fetal rib growth plate. Moreover, in situ hybridization has shown expression of OSAD in osteoblasts close to the cartilage and bone border in the growth plate of rat femur. OSAD may play an important role during tooth development and biomineralization of dentin. Osteomodulin is a cell binding keratan sulfate proteoglycan which was recently isolated from mineralized bovine bone and subsequently cloned and sequenced. Osteomodulin may be implicated in biomineralization processes. It has a function in binding of osteoblasts via the alpha (V) beta (3)-integrin. It is likely that Osteomodulin is an osteoblast maturation marker that is induced by osteoclast activity. Osteomodulin is also an early marker for terminally differentiated matrix producing osteoblasts.

Full Name
osteomodulin
References
  • Buchaille R, et al. (2000) Expression of the small leucine-rich proteoglycan osteoadherin/osteomodulin in human dental pulp and developing rat teeth. Bone. 27(2): 265-70.
  • Petersson U, et al. (2003) Identification, distribution and expression of osteoadherin during tooth formation. Eur J Oral Sci. 111(2): 128-36.
  • Rehn AP, et al. (2006) Differential regulation of osteoadherin (OSAD) by TGF-beta1 and BMP-2. Biochem Biophys Res Commun. 349(3): 1057-64.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-OMD Antibody Rabbit Monoclonal ELISA(Cap) 50451-R031
    Anti-OMD Antibody Rabbit Monoclonal ELISA(Det) 50451-R107
    Anti-OMD Antibody Rabbit Polyclonal ELISA 50451-RP02
    Anti-OMD Antibody Rabbit Polyclonal ELISA 10825-T16
    Anti-OMD Antibody Rabbit Monoclonal ELISA 10825-R014
    Anti-OMD Antibody Rabbit Polyclonal ELISA 10825-RP01
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