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Oncostatin M/OSM Protein, Antibody, ELISA Kit, cDNA Clone

Oncostatin M/OSM Related Areas

Oncostatin M/OSM Related Pathways

Oncostatin M/OSM Related Product

Oncostatin M/OSM Summary & Protein Information

Oncostatin M/OSM Related Information

Oncostatin M/OSM Background

Gene Summary: Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This OSM gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. Oncostatin M regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells.
General information above from NCBI
Subcellular location: Secreted.
Post-translational: Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.
Sequence similarity: Belongs to the LIF/OSM family.C
General information above from UniProt

Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that signals through cell surface receptors typeⅠand typeⅡ both of which share the similarity of containing protein gp130 and takes part in many biometabolism processes including liver development, haematopoeisis, inflammation, bone formation and destruction and possibly CNS development. Oncostatin M (OSM) was previoustly identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6 and G-CSF, has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degree but is not stable at 90 degrees. The human OSM is produced as a precursor containing 252 amino acids, whose first 25 amino acids function as a secretory signal peptide and which on removal yields the soluble 227 amino acid pro-OSM. Removal of the C-teminal most 31 amino acids produces the fully active 196 residue form.

Oncostatin M/OSM Alternative Name

MGC20461,Oncostatin M,OSM, [human]
OncoM,Oncostatin M,Osm,RP23-453B22.1, [mouse]

Oncostatin M/OSM Related Studies

  • Tanaka M, et al. (2003) Oncostatin M, a multifunctional cytokine. Rev Physiol Biochem Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 149: 39-52.
  • Auguste P, et al. (1997) Signaling of type II oncostatin M receptor. J Biol Chem. 272 (25): 15760-4.
  • Zarling JM, et al. (1986). Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells. Proc Natl Acad Sci. 83 (24): 9739-43.