Oncostatin M / OSM Protein & Antibody

Oncostatin M / OSM Products

Oncostatin M / OSM Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Oncostatin M / OSM	Human	Oncostatin M/OSM Protein, Recombinant	10452-H08H
Oncostatin M / OSM	Mouse	Oncostatin M/OSM Protein, Recombinant	50112-M08H

Oncostatin M / OSM Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Oncostatin M / OSM	WB, ELISA	Oncostatin M / OSM Antibody (Antigen Affinity Purified)	10452-RP02

Oncostatin M / OSM cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Oncostatin M / OSM	Human	Human OSM cDNA Clone / ORF Clone	HG10452-M
Oncostatin M / OSM	Mouse	Mouse OSM cDNA Clone / ORF Clone	MG50112-M

Oncostatin M / OSM Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-6 Family & Receptor>>Oncostatin M

Oncostatin M / OSM Alternative Names

Oncostatin M, OSM, MGC20461 [Homo sapiens]

Oncostatin M, Osm, RP23-453B22.1, OncoM [Mus musculus]

Oncostatin M / OSM Background

Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that signals through cell surface receptors typeⅠand typeⅡ both of which share the similarity of containing protein gp130 and takes part in many biometabolism processes including liver development, haematopoeisis, inflammation, bone formation and destruction and possibly CNS development. Oncostatin M (OSM) was previoustly identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6 and G-CSF, has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degree but is not stable at 90 degrees. The human OSM is produced as a precursor containing 252 amino acids, whose first 25 amino acids function as a secretory signal peptide and which on removal yields the soluble 227 amino acid pro-OSM. Removal of the C-teminal most 31 amino acids produces the fully active 196 residue form.

Oncostatin M / OSM Related Studies

Tanaka M, et al. (2003) Oncostatin M, a multifunctional cytokine. Rev Physiol Biochem Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 149: 39-52.
Auguste P, et al. (1997) Signaling of type II oncostatin M receptor. J Biol Chem. 272 (25): 15760-4.
Zarling JM, et al. (1986). Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells. Proc Natl Acad Sci. 83 (24): 9739-43.