Oligodendrocyte Myelin Glycoprotein (OMgp)

OMgp is cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

Oligodendrocyte Myelin Glycoprotein (OMgp) Related Areas

Neuroscience>>Axon Guidance>>Other Axon Guidance Proteins>>OMGP

Oligodendrocyte Myelin Glycoprotein (OMgp) Alternative Names

OMGP, OMG [Homo sapiens]

Human Oligodendrocyte Myelin Glycoprotein (OMgp) Protein General Information

 

• Protein names: Oligodendrocyte-myelin glycoprotein
• Sequence length: 440 AA.
• Sequence similarities: OMgp contains 8 LRR (leucine-rich) repeats. OMgp contains 1 LRRNT domain.
• Post-translational modification: O-glycosylated in its Ser/Thr-rich repeat domain
• Subunit structure: OMgp binds to RTN4R
• Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor.
• Tissue specificity: Oligodendrocytes and myelin of the central nervous system.
• Caution: OMgp do not confuse oligodendrocyte-myelin glycoprotein (OMG) with myelin-oligodendrocyte glycoprotein (MOG).

General information above from UniProt

Function for Oligodendrocyte Myelin Glycoprotein (OMgp) Protein

UniProtKB:

OMgp is cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

Genatlas:

• OMgp contributes to the interactive process required for myelination in central nervous system
• OMgp inhibites neurite outgrowth and axonal regeneration after brain injury
• OMgp is implicated in growth cone collapse and neurite outgrowth inhibition by signaling through the RTN4R and paired Ig-like receptor B (LILRB3)
• physiological roles of RTN4, MAG, OMGP in processes, such as development, neuronal homeostasis, plasticity, and neurodegeneration

Homology for human Oligodendrocyte Myelin Glycoprotein (OMgp)

• homolog to murine Omg