Obesity Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
ADRB2					HG10378-M
SerpinA6					HG10998-M, MG50314-M
DPP4/CD26	DPPIV, ADABP, ADCP2, TP103	Dipeptidyl Peptidase IV (DPPIV/DPP4/CD26), is a highly conserved type II integral membrane protein associated with immune regulation, signal transduction and apoptosis. Elevated expression of DPPIV is associated with autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. The levels of DPP4 soluble form in serum and body fluids have clinical significance in patients with cancer, liver, kidney diseases and depression.	10688-H01H, 10688-HNCH		HG10688-M
PRKAA2/AMPK					HG10394-M
JNK1/MAPK8	JNK, JNK1A2, JNK21B1/2, PRKM8, SAPK1	Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAPK8 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAPK8 is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. In addition, JNK1, together with JNK2, are required for polarized differentiation of T-helper cells into Th1 cells.	10795-H09B		HG10795-M, MG50009-M
PTP1B/PTPN1					HG10304-M
CNTFR					HG11012-M
PL					11044-M
AGRP	AGRT, ART, ASIP2, MGC118963	AgRP is a neuropeptide. It has been identified as one of the two naturally occurring inverse agonists of melanocortin receptors, specifically MC3-R and MC4-R. Upregulated expression of AgRP is observed in obesity and diabetes, and genetically AgRP polymorphisms are associated with susceptibility to anorexia nervosa.	10070-H02H		HG10070-M, MG50276-M
Leptin Receptor/CD295	OBR	Leptin receptor (LEPR) is a single-transmembrane-domain receptor of the cytokine receptor family. It exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure.	10322-H03H		HG10322-M
JNK2/MAPK9	JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, p54aSAPK, SAPK, p54a, NK-55	Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, such as c-Jun and ATF2. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis.	10745-H08B		HG10745-M
PLTP	HDLCQ9				HG11171-M
Fetuin-A	AHSG, A2HS, AHS, FETUA, HSGA	Fetuin-A is a member of cystatin superfamily of protease inhibitors. It is closely associated with tumor progression and resistance to chemotherapy in established cancers, as well as host immune suppression. In addition, it has been shown that fetuin A inhibits both insulin receptor autophosphorylation and undesirable calcification, and plays a role in bone development, calcium homeostasis, regulation of soft tissue calcification, and insulin sensitivity.	10318-H08H, 50093-M08H	10318-MM02, 10318-RP01, 10318-RP03	HG10318-M, MG50093-M
NPY	PYY4				HG10946-M