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Product Catalog
> OX40 Protein & Antibody (CD134, TNFRSF4) OX40 Protein & Antibody (CD134, TNFRSF4)
Cluster of Differentiation 134, Tumor Necrosis Factor Receptor Superfamily, member 4
OX40 Products
OX40 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| OX40/CD134 | Human | OX40/CD134/Fc Protein, Recombinant | 10481-H03H |
| OX40/CD134 | Human | OX40/CD134 Protein, Recombinant | 10481-H08H |
OX40 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human OX40/CD134 |
WB, ELISA | OX40/CD134 Antibody, Rabbit PAb | 10481-RP01 |
| Human OX40/CD134 |
WB, ELISA | OX40/CD134 Antibody, Rabbit PAb (Antigen Affinity Purified) | 10481-RP02 |
OX40 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| OX40/CD134 | Human | Homo sapiens OX40/CD134 cDNA Clone(NM_003327.2) | HG10481-M |
| OX40/CD134 | Mouse | Mouse OX40/CD134 cDNA Clone / ORF Clone | MG50808-G |
OX40 Related Areas
Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>OX40/CD134/TNFRSF4
Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>OX40/CD134/TNFRSF4
Immunology>>Cytokine & Receptor>>TNF Superfamily>>OX40/CD134/TNFRSF4
Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells>> OX40/CD134/TNFRSF4
OX40 Alternative Names
OX40, CD134, TNFRSF4, RP5-902P8.3, ACT35, TXGP1L
OX40 Background
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.
OX40 Related Studies
- Adam PJ, et al. (2006) CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. Br J Cancer. 95(3): 298-306.
- Keller AM, et al. (2007) Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules. Proc Natl Acad Sci U S A. 104(14): 5989-94.
- Grewal IS. (2008) CD70 as a therapeutic target in human malignancies. Expert Opin Ther Targets. 12(3): 341-51.
- Boursalian TE, et al. (2009) Targeting CD70 for human therapeutic use. Adv Exp Med Biol. 647: 108-19.
OX40/CD134 related areas, pathways, and other information
TNF Superfamily Ligands
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TNF Receptor Superfamily
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