Anti-OX40 Antibody

Cat: 10481-R004
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All OX40 Reagents
Anti-OX40 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-OX40 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human OX40
Recombinant Human TNFRSF4 protein (Catalog#10481-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human TNFRSF4 (rh TNFRSF4; Catalog#10481-H08H; NP_003318.1; Met 1-Ala 216).
Monoclonal Rabbit IgG Clone #004
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-OX40 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1-2 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-OX40 Antibody Alternative Names
Anti-ACT35 Antibody;Anti-CD134 Antibody;Anti-IMD16 Antibody;Anti-OX40 Antibody;Anti-TXGP1L Antibody
OX40 Background Information

OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
tumor necrosis factor receptor superfamily, member 4
  • Compaan D.M., et al. (2006) .The crystal structure of the costimulatory OX40-OX40L complex. Structure 14:1321-1330.
  • Kawamata S., et al. (1998) .Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. J. Biol. Chem. 273:5808-5814.
  • Byun M., (2013) Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J. Exp. Med. 210:1743-1759.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-OX40 Antibody Rabbit Polyclonal WB,IP 102007-T36
    Anti-OX40 Antibody Rabbit Polyclonal WB 106895-T32
    Anti-OX40 Antibody Rabbit Polyclonal ELISA 10481-T16
    Anti-OX40 Antibody Rabbit Polyclonal ELISA 10481-RP01
    Anti-OX40 Antibody Mouse Monoclonal ELISA 10481-MM03
    Anti-OX40 Antibody Rabbit Polyclonal ELISA 10481-RP02
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