Anti-OX40 Antibody

Cat: 10481-R004
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All OX40 Reagents
Anti-OX40 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-OX40 Antibody
Validated applications
WB
Species reactivity
Reacts with: Human
Specificity
Human OX40
Immunogen
Recombinant Human TNFRSF4 protein (Catalog#10481-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human TNFRSF4 (rh TNFRSF4; Catalog#10481-H08H; NP_003318.1; Met 1-Ala 216).
Source
Monoclonal Rabbit IgG Clone #004
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-OX40 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1-2 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-OX40 Antibody Alternative Names
Anti-ACT35 Antibody;Anti-CD134 Antibody;Anti-IMD16 Antibody;Anti-OX40 Antibody;Anti-TXGP1L Antibody
OX40 Background Information

OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
tumor necrosis factor receptor superfamily, member 4
References
  • Compaan D.M., et al. (2006) .The crystal structure of the costimulatory OX40-OX40L complex. Structure 14:1321-1330.
  • Kawamata S., et al. (1998) .Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. J. Biol. Chem. 273:5808-5814.
  • Byun M., (2013) Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J. Exp. Med. 210:1743-1759.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-OX40 Antibody Rabbit Polyclonal WB,IP 102007-T36
    Anti-OX40 Antibody Rabbit Polyclonal WB 106895-T32
    Anti-OX40 Antibody Rabbit Polyclonal ELISA 10481-T16
    Anti-OX40 Antibody Rabbit Polyclonal ELISA 10481-RP01
    Anti-OX40 Antibody Mouse Monoclonal ELISA 10481-MM03
    Anti-OX40 Antibody Rabbit Polyclonal ELISA 10481-RP02
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