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TNFRSF4 / OX40 / CD134 Antibody, Rabbit PAb, Antigen Affinity Purified

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Human TNFRSF4/OX40/CD134 Antibody Product Information
Immunogen:Recombinant Human TNFRSF4 protein (Catalog#10481-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human TNFRSF4 (rh TNFRSF4; Catalog#10481-H08H; NP_003318.1; Met 1-Ala 216). TNFRSF4 specific IgG was purified by human TNFRSF4 affinity chromatography.
Human TNFRSF4/OX40/CD134 Antibody Usage Guide
Specificity:Human TNFRSF4 / CD134
Application:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TNFRSF4. The detection limit for Human TNFRSF4 is approximately 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other TNFRSF4/OX40/CD134 Antibody Products
Reactivity: Human  
Application: ELISA  
    10481-RP01-400
    10481-RP01-100
    10481-RP01-200
     
    100 µg 
    200 µg 
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    Reactivity: Human  
    Application: ELISA  
      10481-T16-200
      10481-T16-100
      10481-T16-50
      200 µg 
      100 µg 
      50 µg 
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      OX40/TNFRSF4/CD134 Background

      OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.

      Human OX40/TNFRSF4/CD134 References
    • Compaan D.M., et al. (2006) .The crystal structure of the costimulatory OX40-OX40L complex. Structure 14:1321-1330.
    • Kawamata S., et al. (1998) .Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. J. Biol. Chem. 273:5808-5814.
    • Byun M., (2013) Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J. Exp. Med. 210:1743-1759.
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      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"