All OX40L reagents are produced in house and quality controlled, including 1 OX40L Antibody, 48 OX40L Gene, 5 OX40L Lysate, 5 OX40L Protein, 2 OX40L qPCR. All OX40L reagents are ready to use.
Recombinant OX40L proteins are expressed by HEK293 Cells with fusion tags as N-human IgG1-Fc, N-mouse IgG1-Fc, N-rabbit IgG-Fc.
OX40Lantibodies are validated with different applications, which are IHC-P.
OX40LcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each OX40L of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.