Anti-OTUB2 Antibody

Cat: 13177-T16
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Anti-OTUB2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-OTUB2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human OTUB2
Immunogen
Recombinant Human OTUB2 protein (Catalog#13177-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human OTUB2 (rh OTUB2; Catalog#13177-H07E; Q96DC9-1; Met1-His234). OTUB2 specific IgG was purified by Human OTUB2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-OTUB2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-OTUB2 Antibody Alternative Names
Anti-C14orf137 Antibody;Anti-OTB2 Antibody;Anti-OTU2 Antibody
OTUB2 Background Information

Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1 and α2, and a large helical region comprised of α3-α10. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2)'s active-site cleft is sterically occluded by a novel loop conformation resulting in an oxyanion hole, which consists uniquely of backbone amides. Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 (OTUB2) are different from other cysteine proteases. This reorganization of the active-site topology provides a possible explanation for the low turnover and substrate specificity of the otubains.

Full Name
OTU deubiquitinase, ubiquitin aldehyde binding 2
References
  • Balakirev MY, et al. (2003) Otubains: a new family of cysteine proteases in the ubiquitin pathway. EMBO Rep 4 (5): 517-22.
  • Nanao MH. (2004) Crystal structure of human otubain 2. EMBO reports. 5: 783-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-OTUB2 Antibody Rabbit Polyclonal ELISA 13177-RP01
    Anti-OTUB2 Antibody Rabbit Monoclonal ELISA,ICC/IF,IF 13177-R139
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