Anti-OSTM1 Antibody

Cat: 10913-R030
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All OSTM1 Reagents
Anti-OSTM1 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-OSTM1 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human OSTM1
Recombinant Human OSTM1 protein (Catalog#10913-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human OSTM1 extracellular domain (rh OSTM1; Catalog#10913-H08H; NP_054747.2; Met 1-Pro 284).
Monoclonal Rabbit IgG Clone #30
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-OSTM1 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-OSTM1 Antibody Alternative Names
Anti-GIPN Antibody;Anti-GL Antibody;Anti-HSPC019 Antibody;Anti-OPTB5 Antibody
OSTM1 Background Information

Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I  membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 association with CLCN7 demonstrated that OSTM1 requires CLCN7 to localize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. The researches found that OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for osteoclast activation. Thus, OSTM1 has a important role in osteoclast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to osteoclast lineage, OSTM1-defect patients display the most severe recessive osteopetrotic phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO).

Full Name
osteopetrosis associated transmembrane protein 1

1.  Chalhoub, N. et al., 2003, Nat Med. 9 (4): 399-406.

2.  Quarello, P. et al., 2004, J Bone Miner Res. 19 (7): 1194-1199.

3.  Lange, PF. et al., 2006, Nature. 440 (7081): 220-223

4.  Maranda, B. et al., 2008, J Bone Miner Res. 23 (2): 296-300.

5.  Feigin, al., 2008, Cell Signal. 20 (5): 949-957.  

6.  Pata, al., 2008, J Biol Chem. 283 (45): 30522-30530. 

Product Description Host Clonality Application Catalog# (PDF)
Anti-OSTM1 Antibody Rabbit Polyclonal ELISA 10913-RP01
Anti-OSTM1 Antibody Rabbit Polyclonal ELISA 10913-RP02
Anti-OSTM1 Antibody Mouse Monoclonal ELISA 10913-MM10
Anti-OSTM1 Antibody Rabbit Polyclonal ELISA 10913-T16
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