Anti-OSTM1 Antibody

Cat: 10913-RP02
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Anti-OSTM1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-OSTM1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human OSTM1
Immunogen
Recombinant Human OSTM1 protein (Catalog#10913-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human OSTM1 extracellular domain (rh OSTM1; Catalog#10913-H08H; NP_054747.2; Met 1-Pro 284). OSTM1 specific IgG was purified by human OSTM1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-OSTM1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-OSTM1 Antibody Alternative Names
Anti-GIPN Antibody;Anti-GL Antibody;Anti-HSPC019 Antibody;Anti-OPTB5 Antibody
OSTM1 Background Information

Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I  membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 association with CLCN7 demonstrated that OSTM1 requires CLCN7 to localize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. The researches found that OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for osteoclast activation. Thus, OSTM1 has a important role in osteoclast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to osteoclast lineage, OSTM1-defect patients display the most severe recessive osteopetrotic phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO).

Full Name
osteopetrosis associated transmembrane protein 1
References

1.  Chalhoub, N. et al., 2003, Nat Med. 9 (4): 399-406.

2.  Quarello, P. et al., 2004, J Bone Miner Res. 19 (7): 1194-1199.

3.  Lange, PF. et al., 2006, Nature. 440 (7081): 220-223

4.  Maranda, B. et al., 2008, J Bone Miner Res. 23 (2): 296-300.

5.  Feigin, ME.et al., 2008, Cell Signal. 20 (5): 949-957.  

6.  Pata, M.et al., 2008, J Biol Chem. 283 (45): 30522-30530. 

Product Description Host Clonality Application Catalog# (PDF)
Anti-OSTM1 Antibody Rabbit Polyclonal ELISA 10913-RP01
Anti-OSTM1 Antibody Rabbit Polyclonal ELISA 10913-T16
Anti-OSTM1 Antibody Mouse Monoclonal ELISA 10913-MM10
Anti-OSTM1 Antibody Rabbit Monoclonal ELISA 10913-R030
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