All OSMR reagents are produced in house and quality controlled, including 10 OSMR Antibody, 1 OSMR ELISA, 13 OSMR Gene, 1 OSMR IPKit, 2 OSMR Lysate, 2 OSMR Protein, 2 OSMR qPCR. All OSMR reagents are ready to use.
Recombinant OSMR proteins are expressed by HEK293 Cells with fusion tags as C-His.
OSMRantibodies are validated with different applications, which are FCM, ELISA, ELISA(Det), IP, WB, ELISA(Cap).
OSMRcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each OSMR of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
OSMRELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.