OSMR / IL-31RB Antibody (Cytokine)

OSMR / IL-31RB Antibody Datasheet

OSMR / IL-31RB Antibody Product Information

• Immunogen: Recombinant Mouse OSMR / IL-31RB protein (Catalog#50500-M08H)
• Antibody Type: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
• Ig Type: Rabbit IgG
• Formulation: 0.2 μm filtered solution in PBS with 5% trehalose
• Preparation: Produced in rabbits immunized with purified, recombinant Mouse OSMR / IL-31RB (rM OSMR / IL-31RB; Catalog#50500-M08H; O70458-1; Met 1-Leu 738). Total IgG was purified by Protein A affinity chromatography.

OSMR / IL-31RB Antibody Usage Guide

• Specificity: Mouse OSMR / IL-31RB
• Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse OSMR in WB. Using a DAB detection system, the detection limit for Mouse OSMR is approximately 4 ng/lane under non-reducing conditions and 1 ng/lane under reducing conditions.
• Direct ELISA: This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Mouse OSMR. The detection limit for Mouse OSMR is approximately 0.00975 ng/well.
• Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
  Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

OSMR / IL-31RB Antibody Background

Oncostatin-M-specific receptor subunit beta, also known as interleukin-31 receptor subunit beta, and OSMR, is a single-pass type I membrane protein which belongs to thetype I cytokine receptor family and Type 2 subfamily. OSMR contains four fibronectin type-III domains and is expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines. Four forms of OSMR have been identified: leukemia inhibitory factor receptor (LIFR), OSMR beta, short-form OSMR (OSMRs) and soluble OSMR (sOSMR). OSMR associates with IL31RA to form the IL31 receptor. It binds IL31 to activate STAT3 and possibly STAT1 and STAT5. OSMR is part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases (Jaks) and transcription factors of the signal transducers and activators of transcription (STAT) family. Defects in OSMR are the cause of amyloidosis type 9 (AMYL9) which is a hereditary primary amyloidosis characterized by localized cutaneous amyloid depositio.

References

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