Anti-OSMR Antibody

Cat: 11226-R007
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Anti-OSMR Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-OSMR Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human OSMR
Immunogen
Recombinant Human OSMR / IL-31RB Protein (Catalog#11226-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human OSMR / IL-31RB (rh OSMR / IL-31RB; Catalog#11226-H08H; NP_003990.1; Met 1-Met 740).
Source
Monoclonal Rabbit IgG Clone #007
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-OSMR Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-OSMR Antibody Alternative Names
Anti-IL-31RB Antibody;Anti-OSMRB Antibody;Anti-PLCA1 Antibody
OSMR Background Information

Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.

Full Name
oncostatin M receptor
References
  • Arita K, et al.. (2008) Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis. Am J Hum. Genet. 82 (1): 73-80.
  • Malaval L, et al.. (2005) GP130/OSMR is the only LIF/IL-6 family receptor complex to promote osteoblast differentiation of calvaria progenitors. J Cell Physiol. 204(2): 585-93.
  • Lin MW, et al.. (2010) Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. Eur J Hum Genet. 18(1): 26-32.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-OSMR Antibody Rabbit Monoclonal ELISA 50500-R202
    Anti-OSMR Antibody Rabbit Polyclonal ELISA 50500-RP01
    Anti-OSMR Antibody Rabbit Polyclonal ELISA 50500-T16
    Anti-OSMR Antibody (PE) Rabbit Monoclonal FCM 11226-R002-P
    Anti-OSMR Antibody Mouse Monoclonal ELISA,ELISA(Det),IP 11226-MM01
    Anti-OSMR Antibody Rabbit Polyclonal ELISA 11226-RP01
    Anti-OSMR Antibody (APC) Rabbit Monoclonal FCM 11226-R002-A
    Anti-OSMR Antibody Rabbit Polyclonal WB,ELISA 11226-RP02
    Anti-OSMR Antibody Rabbit Monoclonal ELISA(Cap),FCM 11226-R002
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