ORP150

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding

ORP150 Related Areas

Cancer>>Apoptosis>>Heat-Shock Protein>>ORP150/HYOU1/Grp170/HSP12A

ORP150 Alternative Names

ORP150, HYOU1, Grp170, HSP12A, DKFZp686N08236, FLJ94899, FLJ97572, GRP-170, ORP-150 [Homo sapiens]

Orp150, Hyou1, Grp170, AI415631, CBP-140, Cab140, GRP-170 [Mus musculus]

Summaries for ORP150

Entrez Gene summary for ORP150:

The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.

OMIM - description for ORP150:

Astrocytes retain cell viability, even in extreme ischemia, and proliferate in damaged brain (Petito et al., 1990; Janeczko, 1991). Rat astrocytes exposed to hypoxia followed by reoxygenation were reported to release increased amounts of interleukin-6 (147620) that could promote neuronal survival in ischemic brain (Maeda et al., 1994). Kuwabara et al. (1996) observed a 150-kD protein, called oxygen-regulated protein (ORP150) by them, in the endoplasmic reticulum (ER) of cultured astrocytes that was induced specifically by hypoxia and not by other stimuli.

Wikipedia summary for ORP150:

Hypoxia up-regulated protein 1 is a protein that in humans is encoded by the HYOU1 gene. The protein encoded by this gene belongs to the heat shock protein 70 family. This gene has three mRNAs from the use of alternative transcription sites. A cis-acting segment is found at the 5' end of exon 1A which is involved in the stress-dependent induction. The transcript that begins with exon 1B is preferentially induced by hypoxia, resulting in the accumulation of this protein in the endoplasmic reticulum (ER). The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. There is also an alternative translation site of this gene which lacks the signal peptide. This signal peptide-lacking protein, is only 3 amino acids shorter than the mature protein in the ER, and it is thought to have a housekeeping function in the cytosol

Human ORP150 Protein General Information

 

• Protein names: Recommended name: Hypoxia up-regulated protein 1 Alternative name(s): 150 kDa oxygen-regulated protein Short name=ORP-150 170 kDa glucose-regulated protein Short name=GRP-170
• Sequence length: 999 AA.
• Domain: Signal
• Sequence similarities: Belongs to the heat shock protein 70 family.
• Induction: By hypoxia and also by 2-deoxyglucose or tunicamycin.
• Subunit structure: art a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
• Subcellular location: Endoplasmic reticulum lumen.
• Tissue specificity: Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.

General information above from UniProt

Function for ORP150 Protein

UniProtKB:

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding

Genatlas:

• ORP150 has a cytoprotective role in hypoxia-induced cellular perturbations

Homology for human ORP150

• homolog to Drosophila EG:25E8.1
• homolog to C.elegans T14G8.3