ORM2

ORM2 belongs to the calycin superfamily, lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids. Lipocalins can be found in gram negative bacteria, vertebrate cells, and invertebrate cells, and in plants. They are associated with many biological processes. ORM2 functions as transport protein in the blood stream. It is expressed by the liver and secreted in plasma. It seems that ORM2 function in modulating the activity of the immune system during the acute-phase reaction. It binds various hydrophobic ligands in the interior of its beta-barrel domain. It also binds synthetic drugs and influences their distribution and availability.

ORM2 Alternative Names

RP11-82I1.2, AGP-B, AGP-B', AGP2, AGP 2, OMD 2, alpha-1-acid glycoprotein 2, alpha-1-acid glycoprotein, type 2, orosomucoid-2 [Homo sapiens]

Agp1, Orm-2, AGP 2, OMD 2, alpha-1-acid glycoprotein 1, alpha-1-acid glycoprotein 2, bM340H1.5 (orosomucoid 2), orosomucoid-2 [Mus musculus]

Summaries for ORM2

Entrez Gene summary for ORM2:

ORM2 gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

Human ORM2 Protein General Information

 

• Protein names: ORM2
• Sequence length: 201 AA.
• Domain: Contains a beta-barrel that binds various ligands in its interior.
• Sequence similarities: Belongs to the calycin superfamily. Lipocalin family.
• Post-translational modification: N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).
• Induction: Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.
• Subcellular location: Secreted.
• Tissue specificity: Expressed by the liver and secreted in plasma.
• Polymorphism: Many different variants of ORM2 are known.
• Sequence caution: The sequence CAA29873.2 differs from that shown. Reason: Erroneous gene model prediction.
  The sequence CAA29874.1 differs from that shown. Reason: Erroneous gene model prediction.

General information above from UniProt

Function for ORM2 Protein

UniProtKB:

ORM2 functions as transport protein in the blood stream. ORM2 binds various hydrophobic ligands in the interior of its beta-barrel domain. Also ORM2 binds synthetic drugs and influences their distribution and availability. ORM2 appears to function in modulating the activity of the immune system during the acute-phase reaction.

Genatlas:

• ORM2 is involved in aspects of immunosuppression
• ORM2 modulates the activity of the immune system during the acute-phase reaction

Homology for human ORM2

• ortholog to murine Orm2
• homolog to C.elegans ZK1320.2