Anti-Oligodendrocyte myelin glycoprotein Antibody (Rabbit Polyclonal antibody) General Information
Anti-Oligodendrocyte myelin glycoprotein Antibody
Reacts with: Human
Human Oligodendrocyte myelin glycoprotein
Recombinant Human OMGP protein (Catalog#10269-H08H)
Produced in rabbits immunized with purified, recombinant Human OMGP (rh OMGP; Catalog#10269-H08H; P23515-1; Met 1-Pro 416). OMGP specific IgG was purified by Human OMGP affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Oligodendrocyte myelin glycoprotein Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-Oligodendrocyte myelin glycoprotein Antibody (Rabbit Polyclonal antibody) Images
Immunochemical staining of human OMGP in human stomach with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Anti-Oligodendrocyte myelin glycoprotein Antibody Alternative Names
Oligodendrocyte myelin glycoprotein Background Information
Oligodendrocyte-myelin glycoprotein, also known as OMG and OMGP, is a cell membrane protein which contains eight LRR (leucine-rich) repeats. OMG / OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG / OMGP is a cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. OMG / OMGP play roles in both the developing and adult central nervous system. OMG / OMGP participats in growth cone collapse and inhibition of neurite outgrowth through its interaction with NgR, the receptor for Nogo. This function requires its leucine-rich repeat domain, a highly conserved region in OMgp during mammal evolution. OMG / OMGP leucine-rich repeat domain is also implicated in the inhibition of cell proliferation. OMG / OMGP may also be involved in the formation and maintenance of myelin sheaths. Cell proliferation, neuronal sprouting and myelination are crucial processes involved in brain development and regeneration after injury.
oligodendrocyte myelin glycoprotein
Viskochil D., et al.,(1991), The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. Mol. Cell. Biol. 11:906-912.Mikol D.D., et al., (1990), The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate.J. Cell Biol. 110:471-479.Mikol D.D., et al.,(1990), Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein.J. Cell Biol. 111:2673-2679.