LOX-1 cDNA ORF Clone in Cloning Vector, Rat

Cat: RG80268-G
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LOX-1 cDNA ORF Clone in Cloning Vector, Rat General Information
Gene
Species
Rat
NCBI Ref Seq
RefSeq ORF Size
1095 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Rat oxidized low density lipoprotein (lectin-like) receptor 1.
Plasmid
Vector
pGEM-T Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
LOX-1 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

LOX-1 cDNA ORF Clone in Cloning Vector, Rat Alternative Names
Lox1 cDNA ORF Clone, Rat;Oldlr1 cDNA ORF Clone, Rat;OLR1 cDNA ORF Clone, Rat
LOX-1 Background Information

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. OLR1 / LOX1 was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX1 is inducted by inflammatory stimuli and oxidative stimuli. This protein binds, internalizes and degrades oxidized low-density lipoprotein. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. In clinical, LOX1 is thought to be involved in the development of atherosclerotic lesions. 

Full Name
oxidized low density lipoprotein (lectin-like) receptor 1
References
  • Hinagata J, et al. (2006) Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model. Cardiovasc Res. 69 (1): 263-71.
  • Melan MA, et al. (1994) The LOX1 Gene of Arabidopsis Is Temporally and Spatially Regulated in Germinating Seedlings. Plant Physiol. 105 (1): 385-93.
  • Saito A, et al. (2010) Relationship between lectin-like oxidized low-density lipoprotein receptor 1 expression and preoperative echogenic findings of vulnerable carotid plaque. Acta Neurochir (Wien). 152 (4): 589-95.
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    LOX-1 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    LOX-1 cDNA ORF Clone, Rat, untagged RG80268-UT
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    LOX-1 cDNA ORF Clone, Rat, N-HA tag RG80268-NY
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    LOX-1 cDNA ORF Clone, Human, Related Products

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    info info
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