OLR1 / LOX1 Protein Price Inquiry ( Available Sizes )
OLR1 / LOX1 Protein Product Information
||OLR1 ,CLEC8A, LOX1, LOXIN, SCARE1, SLOX1
||A DNA sequence encoding the human OLR1 (P78380) extracellular domain (Ser 61-Gln 273) was expressed, with a polyhistidine tag at the N-terminus.
OLR1 / LOX1 Protein QC Testing
||> 85 % as determined by SDS-PAGE.
OLR1 / LOX1 protein
||< 1.0 EU per μg of the protein as determined by the LAL method
||Samples are stable for up to twelve months from date of receipt at -70℃
|Predicted N terminal:
||The recombinant human OLR1 consists of 229 amino acids and has a calculated molecular mass of 26.5 kDa. It exists as a disulfide-linked homodimer. As a result of glycosylation, the apparent molecular mass of rhOLR1 is approximately 30-35 kDa in SDS-PAGE under reducing conditions, and 60-70 KDa in non-reduced SDS-PAGE.
||Lyophilized from sterile PBS , pH 7.4
- Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
- Please contact us for any concerns or special requirements.
OLR1 / LOX1 Protein Usage Guide
||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
OLR1 / LOX1 Protein Related Products & Topics
OLR1 / LOX1 Protein Description
Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a receptor protein which belongs to the C-type lectin superfamily. Lectin-like oxidized LDL receptor-1 (LOX-1) was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX-1 is inducted by inflammatory stimuli, so LOX-1 is thought to be involved in the development of atherosclerotic lesions. It is an important cell surface receptor for the progression of atherosclerosis. LOX-1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. LOX-1 expression is also induced in smooth muscle cells in response to proinflammatory and oxidative stimuli. LOX-1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2.
- Hinagata J. et al., 2006, Cardiovasc Res. 69 (1): 263-71.
- Melan MA. et al., 1994, Plant Physiol. 105 (1): 385-393.
- Saito A. et al., 2010, Acta Neurochir (Wien). 152 (4): 589-95.