OLR1 / LOX1 Protein

Oxidized low density lipoprotein (lectin-like) receptor 1

OLR1 Products

OLR1 Protein, Recombinant

Molecule	Species	Description	Cat. No
OLR1	Human	OLR1 / LOX1 Protein,Recombinant	10585-H07H

OLR1 cDNA Clone

Molecule	Species	Description	Cat. No
OLR1	Human	OLR1 cDNA Clone / ORF Clone	HG13306-G
OLR1	Human	LOX-1 cDNA Clone / ORF Clone	HG10585-M
OLR1	Rat	OLR1 cDNA Clone / ORF Clone	RG80268-G

OLR1 Related Areas

Immunology>>Adhesion Molecule>>Lectin>>OLR1

OLR1 Alternative Names

CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 [Homo sapiens]

LOX-1, SR-EI, Scare1 [Mus musculus]

OLR1 Background

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. OLR1 / LOX1 was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX1 is inducted by inflammatory stimuli and oxidative stimuli. This protein binds, internalizes and degrades oxidized low-density lipoprotein. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. In clinical, LOX1 is thought to be involved in the development of atherosclerotic lesions. 

OLR1 Related Studies

1. Hinagata J, et al. (2006) Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model. Cardiovasc Res. 69 (1): 263-71.
2. Melan MA, et al. (1994) The LOX1 Gene of Arabidopsis Is Temporally and Spatially Regulated in Germinating Seedlings. Plant Physiol. 105 (1): 385-93.
3. Saito A, et al. (2010) Relationship between lectin-like oxidized low-density lipoprotein receptor 1 expression and preoperative echogenic findings of vulnerable carotid plaque. Acta Neurochir (Wien). 152 (4): 589-95.