OBCAM / OPCML Protein

Opiate Binding-Cell Adhesion Molecule/Opioid binding protein/cell adhesion molecule-like

OBCAM / OPCML Products

OBCAM / OPCML Protein, Recombinant

Molecule	Species	Description	Cat. No
OBCAM/OPCML	Human	OBCAM/OPCML Protein, Recombinant	10328-H08H

OBCAM / OPCML cDNA Clone

Molecule	Species	Description	Cat. No
OBCAM/OPCML	Human	OBCAM/OPCML transcript variant 1 cDNA Clone / ORF Clone	HG10328-M
OBCAM/OPCML	Mouse	OPCML cDNA Clone / ORF Clone	MG51073-G
OBCAM/OPCML	Rat	OPCML cDNA Clone / ORF Clone	RG80397-G

OBCAM / OPCML Alternative Names

OBCAM, OPCML, OPCM, IGLON1 [Homo sapiens]

Obcam, Opcml, Gm181, AI844366, MGC99974, 3732419F12, C230027C17, 2900075O15Rik, B930023M13Rik [Mus musculus]

OBCAM / OPCML Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>OBCAM/OPCML

OBCAM / OPCML Background

Opioid-binding Cell Adhesion Molecule (OBCAM), also known as OPCML, is a GPI-anchored cell adhesion molecule in the plasma membrane. This neuron-specific protein, consists of three immunoglobulin (Ig)-like domains anchored to the membrane through a glycosylphosphatidylinositol (GPI)-tail. OPCML also belongs to the member of the IgLON family, a subgroup of the immunoglobulin superfamily, consisting of three members, LAMP, OBCAM, and Neurotrimin. These molecules interact homophilically and heterophilically within the family, and OBCAM acts only as heterodimers with LAMP or Neurotrimin and possibly inhibits neurite outgrowth from cerebellar granule cells. OBCAM has been presumed to play a role as a cell adhesion/recognition molecule. Furthermore, the OPCML protein defects may play an important role in the carcinogenesis of cervical or ovarian cancers, and this gene is regarded as a candidate TSG (tumor suppressor gene).

OBCAM / OPCML Related Studies

1. Hachisuka A, et al. (2000) Developmental expression of opioid-binding cell adhesion molecule (OBCAM) in rat brain. Brain Res Dev Brain Res. 122(2): 183-91.
2. Miyata S, et al. (2003) Polarized targeting of IgLON cell adhesion molecule OBCAM to dendrites in cultured neurons. Brain Res. 979(1-2): 129-36.
3. Yamada M, et al. (2007) Synaptic adhesion molecule OBCAM; synaptogenesis and dynamic internalization. Brain Res. 1165: 5-14.
4. Sugimoto C, et al. (2010) OBCAM, an immunoglobulin superfamily cell adhesion molecule, regulates morphology and proliferation of cerebral astrocytes. J Neurochem. 112(3): 818-28.