Nogo Receptor

Nogo receptor is receptor for RTN4, OMG and MAG. Nogo receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Nogo receptor acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development.

Nogo Receptor Related Areas

Neuroscience>>Axon Guidance>>Other Axon Guidance Proteins>>Nogo R/RTN4R

Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>Nogo R/RTN4R

Nogo Receptor Alternative Names

Nogo Receptor, NOGOR, RTN4R, NGR

Summaries for Nogo Receptor

Entrez Gene summary for RTN4R:

This RTN4R gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. Nogo receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]

Wikipedia summary for Nogo Receptor:

Reticulon 4 receptor (RTN4R) also known as Nogo-66 Receptor (NgR) is a protein which in humans is encoded by the RTN4R gene.

Human Nogo Receptor Protein General Information

 

• Protein names: Nogo receptor
• Sequence length: 473 AA.
• Sequence similarities: Nogo receptor belongs to the Nogo receptor family. Nogo receptor contains 8 LRR (leucine-rich) repeats. Nogo receptor contains 1 LRRCT domain. Nogo receptor contains 1 LRRNT domain.
• Subunit structure: Homomultimer. Interacts with LINGO1. Nogo receptor interacts with KIAA0319L.
• Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor.
• Tissue specificity: Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney not expressed in oligodendrocytes (white matter).

General information above from UniProt

Function for Nogo Receptor Protein

UniProtKB:

Nogo receptor is receptor for RTN4, OMG and MAG. Nogo receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Nogo receptor acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development.

Genatlas:

• Nogo receptor is mediator of Nogo-66 (N terminal region of RTN4), inhibiting of axonal regeneration after nervous injury
• Nogo receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system
• Nogo receptor has a function in maintaining neuronal survival that may be relevant for motor neuron development and degeneration
• Nogo receptor function as the ligand-binding component of a receptor complex that also includes LINGO1, NGFR or TNFRSF19 (Venkatesh 2007)
• Nogo receptor alters the motility of immune cells exposed to myelin and may thus impact their behaviour within the CNS, particularly under conditions when immune cell activation is heightened (Pool 2009)
• Nogo receptor's regulation plays an important role in long-term memory formation (Karlen 2009)
• Nogo receptor regulates formation of lasting memories (Karlen 2009)

Homology for human Nogo Receptor

• ortholog to murine Nogo66R

Phenotype Information for Nogo Receptor

• Gene/Locus: RTN4R, NOGOR
• Phenotype: {Schizophrenia, susceptibility to}

Phenotype Information for Nogo Receptor from OMIM (Online Mendelian Inheritance in Man)