Noggin Protein (NOG Protein)

Noggin Products

Noggin Protein, Recombinant

Molecule	Species	Description	Cat. No
Noggin	Human	Noggin/Fc Protein, Recombinant	10267-H02H
Noggin	Human	Noggin Protein, Recombinant	10267-H08H

  10267-H02H: 

1. The ED50 for this effect is typically 1.5-2.0 µg/mL in the presence of 0.25-0.5 µg/mL of BMP-2. Measured by its ability to inhibit BMP-2 induced alkaline phosphatase production by MC3T3-E1 cells.

2. The ED50 for this effect is typically 0.4 µg/mL in the presence of 100 ng/mL of BMP-4. Measured by its ability to inhibit BMP4 induced alkaline phosphatase production by MC3T3-E1 Mouse osteoblastic cells.

Noggin cDNA Clone

Molecule	Species	Description	Cat. No
Noggin	Human	Homo sapiens Noggin cDNA Clone(NM_005450.4)	HG10267-M
Noggin	Mouse	Mouse Noggin cDNA Clone / ORF Clone	MG50688-G

Noggin Alternative Names

Noggin, NOG, SYM1, SYNS1 [Homo sapiens]

Noggin, Nog, RP23-205A9.1 [Mus musculus]

Noggin Related Areas

Stem Cell>>Neural Stem Cell (NSC)>>Neural Stem Cell Markers>>Noggin

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Cell Lineage Marker>>Noggin

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>BMP Family>>Noggin

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>> TGF-beta Superfamily Modulators>>Noggin

Noggin Related Products

Protein Products

Molecule	Species	Description
BMP-2	Human	BMP-2/Fc Protein, Recombinant
BMP-2	Human	BMP-2 Protein, Recombinant (Activity)
BMP-5	Human	BMP-5/Fc Protein, Recombinant
ALK-3/BMPR1A	Human	ALK-3/BMPR1A/Fc Protein, Recombinant
ALK-3/BMPR1A	Human	ALK-3/BMPR1A/Fc Protein, Recombinant
BMPR2	Human	BMPR2/Fc Protein, Recombinant
BMPR2	Human	BMPR2 Protein, Recombinant
NBL1/DAND1	Human	NBL1/DAND1/Fc Protein, Recombinant
NBL1/DAND1	Human	NBL1/DAND1 Protein, Recombinant
FLRG/FSTL3	Mouse	FLRG/FSTL3 Protein, Recombinant
Sclerostin/SOST	Human	Sclerostin/SOST Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human Sclerostin/SOST	WB	Mouse Monoclonal Antibody
Human Sclerostin/SOST	ELISA	Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule	Species	Description
BMP-2	Human	Homo sapiens BMP-2 cDNA Clone(NM_001200.2)
BMP-3b/GDF-10	Human	Homo sapiens BMP-3b/GDF-10 cDNA Clone(NM_004962.2)
BMP-4	Human	Homo sapiens BMP-4 cDNA Clone(NM_001202.3)
BMP-5	Human	Homo sapiens BMP-5 cDNA Clone(NM_021073.2)
BMP-7	Human	Homo sapiens BMP-7 cDNA Clone(NM_001719.2)
GDF-2/BMP-9	Human	Homo sapiens GDF-2/BMP-9 cDNA Clone(NM_016204.1)
ALK-3/BMPRIA	Human	Homo sapiens ALK-3/BMPR1A cDNA Clone(NM_004329.2)
ALK-6/BMPR1B	Human	Homo sapiens ALK-6/BMPR1B cDNA Clone(NM_001203.2)
BMPR2	Human	Homo sapiens BMPR2 cDNA Clone(NM_001204.6)
BAMBI/NMA	Human	Homo sapiens BAMBI/NMA cDNA Clone(NM_012342.2)
Cerberus 1	Human	Homo sapiens Cerberus 1 cDNA Clone(NM_005454.2)
Chordin-Like 1/CHRDL1	Human	Homo sapiens CHRDL1 cDNA Clone(NM_145234.2 )
CER2/DAND5	Human	Homo sapiens CER2/DAND5 cDNA Clone(NM_152654.2)
NBL1/DAND1	Human	Homo sapiens NBL1/DAND1 transcript variant 2 cDNA Clone(NM_005380.4)
Follistatin	Human	Homo sapiens Follistatin cDNA Clone(NM_013409.1)
Tsukushin/TSK	Human	Homo sapiens Tsukushin/TSK cDNA Clone(NM_015516.3)

Noggin Background

Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities, with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs, Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion.

Noggin Related Studies

1. Zimmerman LB, et al. (1996) The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell. 86(4): 599-606.
2. Chandramore K, et al. (2010) Cloning of noggin gene from hydra and analysis of its functional conservation using Xenopus laevis embryos. Evol Dev. 12(3): 267-74.