Nicastrin / NCSTN Protein & Antibody

Nicastrin / NCSTN Protein Products

Nicastrin / NCSTN Protein, Recombinant

Molecule	Species	Description	Cat. No
Nicastrin/NCSTN	Human	Nicastrin/NCSTN Protein, Recombinant	11183-H08H

Nicastrin / NCSTN Antibody

Molecule	Application	Description	Cat. No
Human Nicastrin/NCSTN	WB, ELISA	Rabbit Polyclonal Antibody	11183-RP01
Human Nicastrin/NCSTN	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11183-RP02

Nicastrin / NCSTN cDNA Clone

Molecule	Species	Description	Cat. No
Nicastrin / NCSTN	Human	Homo sapiens Nicastrin/NCSTN cDNA Clone(NM_015331.2)	HG11183-M
Nicastrin / NCSTN	Mouse	Mouse Nicastrin/NCSTN cDNA Clone / ORF Clone	MG50934-G

Nicastrin / NCSTN Related Areas

Signal Transduction>>Notch Signaling Pathway>>Nicastrin/NCSTN

Stem Cell>>Notch Signaling Pathway>>Nicastrin/NCSTN

Nicastrin / NCSTN Alternative Names

Nicastrin, NCSTN, RP11-517F10.1, APH2, KIAA0253 [Homo sapiens]

Nicastrin, Ncstn, 9430068N19Rik, AA727311, Aph2, D1Dau13e, Kiaa0253, Nct, mKIAA0253 [Mus musculus]

Nicastrin / NCSTN Background

Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of these complexes could also contribute to the control of cell death. NCT controls cell death via phosphoinositide 3-kinase/Akt and p53-dependent pathways and that this function remains independent of the activity and molecular integrity of the gamma-secretase complexes. Increasing evidences have shown that Nicastrin/NCSTN plays a crucial role in gamma-cleavage of the amyloid precursor protein (APP). The glycoprotein Nicastrin is an essential component of the gamma-secretase complex, a high molecular weight complex which also contains the presenilin proteins, Aph-1 and Pen-2. The gamma-secretase complex is not only involved in APP processing but also in the processing of an increasing number of other type I integral membrane proteins. As the largest subunit of the gamma-secretase complex, Nicastrin plays a crucial role in its activation. Inhibition of NCSTN demonstrated an altered gamma-cleavage activity, suggesting its potential implication in developing Alzheimer's disease (AD). In addition, Nicastrin can function to maintain epithelial to mesenchymal transition during breast cancer progression. Anti-nicastrin polyclonal and monoclonal antibodies were able to decrease notch1 and vimentin expression and reduced the invasive capacity of breast cancer cells in vitro.

Nicastrin / NCSTN Related Studies

1. He G, et al. (2007) Degradation of nicastrin involves both proteasome and lysosome. J Neurochem. 101(4): 982-92.
2. Hayashi I, et al. (2009) Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. J Biol Chem. 284(41): 27838-47.
3. Ma Z, et al. (2009) Association between promoter polymorphisms of the nicastrin gene and sporadic Alzheimer's disease in North Chinese Han population. Neurosci Lett. 458(3): 136-9.
4. Pardossi-Piquard R, et al. (2009) p53-dependent control of cell death by nicastrin: lack of requirement for presenilin-dependent gamma-secretase complex. J Neurochem. 109(1): 225-37.
5. Filipović A, et al. (2011) Biological and clinical implications of nicastrin expression in invasive breast cancer. Breast Cancer Res Treat. 125(1): 43-53.