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> Neutrophil Granulocyte Neutrophil Granulocyte
Sino biological offers a comprehensive set of tools for neutrophil granulocyte related research, including:
| Product Categories / Species | Human | Mouse | Rat |
| Recombinant Proteins | 31 | 13 | 3 |
| Antibodies | 38 | 12 | - |
| ELISA Kit | 1 | - | - |
| ORF cDNA Clones | 19 | 17 | 3 |
Neutrophil Granulocyte Related Products
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Neutrophil Granulocyte Background
Neutrophil granulocytes, usually referred to as neutrophils, are the most abundant type of leukocytes, which comprise 50-70% of all white blood cells. The mature neutrophil has a segmented nucleus (called a seg or poly) while the immature neutrophil has band-shape nucleus (called a band). Neutrophil granulocytes are filled with neutrally-staining granules, tiny sacs of enzymes that help the cell to kill and digest microorganisms. Normally localized in the circulating blood system, neutrophils migrate to the sites of infection within minutes. Neutrophils direct the path of their migration according to chemical gradients of molecules such as interleukin-8 (IL-8), interferon gamma (IFN-gamma), and C5a, a progress called chemotaxis. Via chemotaxis neutrophil granulocytes migrated to sites of infection, where they directly attack invading pathogens using three strategies: phagocytosis, release of soluble anti-microbials (including granule proteins) and generation of neutrophil extracellular traps (NETs). In addition to the function of direct attacking microorganisms, neutrophils can also activate other cells in the immune system. The number of circulating neutrophils is estimated using the absolute neutrophil count (ANC). An increase of the proportion of neutrophils in the blood, called Neutrophilia, is the hallmark of acute inflammation.
Neutrophil Granulocyte Related Studies
- Morgan JG, et al. (1992). Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases. Adv. Exp. Med. Biol. 305: 89–96.
- Segal, AW (2005). How neutrophils kill microbes. Annu Rev Immunol 23: 197–223.
- Soehnlein O, et al. (2009) Neutrophil granule proteins tune monocytic cell function. Trends Immunol. 30(11):538-46.
- Scheiermann C, et al. (2010) Neutrophil microdomains: linking heterocellular interactions with vascular injury. Curr Opin Hematol. 17(1):25-30.
