Neuropilin-2 (NRP2)

Neuropilin-2 is a high affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

Neuropilin-2 (NRP2) Related Areas

Neuroscience>>Axon Guidance>>Semaphorin & Related Molecules>>Neuropilin-2/NRP2

Neuropilin-2 (NRP2) Alternative Names

Neuropilin 2, NRP2, VEGF165R2, NP2, NPN2, MGC126574, PRO2714 [Homo sapiens]

Neuropilin 2, Nrp2, Np-2, Np2, Npn-2, Npn2, RP23-149A5.1, 1110048P06Rik [Mus musculus]

Summaries for Neuropilin-2 (NRP2)

Entrez Gene summary for NRP2:

This NRP2 gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). Neuropilin-2 may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Wikipedia summary for Neuropilin-2:

Neuropilin is a protein receptor active in neurons.
There are two forms of Neuropilins, Neuropilin-1 and Neuropilin-2. They are transmembrane glycoproteins, and predominantly co-receptors for another class of proteins known as semaphorins. Of the semaphorins, Neuropilin-1 and Neuropilin-2 are specifically receptors for class-3 semaphorins, which, amongst many things, are responsible for axon guidance during the development of the nervous system in vertebrates.
Neuropilins work as co-receptors as they have a very small cytoplasmic domain and thus rely upon other molecules to transduce their signals across a cell membrane, normally plexins. Neuropilins generally work as dimers and different combinations have different affinities for molecules. For example, NRP-1 homodimers have high affinity for Sema-3A, whilst Neuropilin-2 homodimers have high affinity for Sema-3F.

Human Neuropilin-2 (NRP2) Protein General Information

 

• Protein names: Neuropilin-2
• Sequence length: 931 AA.
• Domain: The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
• Sequence similarities: Neuropilin-2 belongs to the neuropilin family. Neuropilin-2 contains 2 CUB domains. Neuropilin-2 contains 2 F5/8 type C domains. Neuropilin-2 contains 1 MAM domain.
• Subunit structure: Heterodimer with NRP1. Binds PLXNB1.
• Subcellular location: Membrane; Single-pass type I membrane protein.

General information above from UniProt

Function for Neuropilin-2 (NRP2) Protein

UniProtKB:

Neuropilin-2 is a high affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

Genatlas:

• Neuropilin-2 is semaphorin 3C and 3F receptor
• Neuropilin-2 is implicated in repulsive axon guidance and vascular endothelial growth factor
• Neuropilin-2 can function in the absence of NRP1 to mediate endothelial tube formation in hypoxia
• Neuropilin-2 is involved in the organization and fasciculation of several cranial nerves and spinal nerves
• Neuropilin-2 functions as receptors for both the semaphorins and vascular endothelial growth factor
• Neuropilin-2 can function in the absence of NRP1 to mediate endothelial tube formation in hypoxia
• Neuropilin-2 plays an important role in cancer and angiogenesis

Homology for human Neuropilin-2 (NRP2)

• homolog to rattus Nrp2 (93.84 pc)
• homolog to murine Nrp2 (94.53 pc)