Anti-Neuropilin-2 Antibody

Cat: 10695-RP02
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Anti-Neuropilin-2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Neuropilin-2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Neuropilin-2
Immunogen
Recombinant Human NRP2 / Neurophilin-2 protein (Catalog#10695-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human NRP2 extracellular domain (rhNRP2; Catalog#10695-H08H; aa 1-855; NP_003863.2). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Neuropilin-2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Neuropilin-2 Antibody Alternative Names
Anti-Neuropilin-2 Antibody;Anti-NP2 Antibody;Anti-NPN2 Antibody;Anti-PRO2714 Antibody;Anti-VEGF165R2 Antibody
Neuropilin-2 Background Information

Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as formation of small lymphatic vessels and capillaries. Recent study has identified NRP-2 as a polysialylated protein expressed in human dendritic cells and modulates DC-T cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis and metastasis.

Full Name
neuropilin 2
References
  • Chen H. et al., 1997, Neuron. 19: 547-59.
  • Bielenberg DR. et al., 2006, Exp Cell Res. 312: 584-93.
  • Yuan L. et al., 2002, Development. 129: 4797-806.
  • Benoit F. et al., 2006, Blood. 108: 1243-50.
  • Sabrina C. et al., 2007, J Biol Chem. 282: 30346-56.
  • Gray MJ. et al., 2008, J Natl Cancer Inst. 100: 109-20.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Neuropilin-2 Antibody Mouse Monoclonal ELISA,ELISA(Det) 10695-MM01
    Anti-Neuropilin-2 Antibody (PE) Mouse Monoclonal FCM 10695-MM03-P
    Anti-Neuropilin-2 Antibody Rabbit Polyclonal ELISA 10695-RP03
    Anti-Neuropilin-2 Antibody Mouse Monoclonal FCM 10695-MM03
    Anti-Neuropilin-2 Antibody (APC) Mouse Monoclonal FCM 10695-MM03-A
    Anti-Neuropilin-2 Antibody Mouse Monoclonal ELISA(Cap) 10695-MM11
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