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NRP2 / Neurophilin-2 Antibody, Mouse MAb

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Human NRP2 Antibody Product Information
Immunogen:Recombinant Human NRP2 / Neurophilin-2 protein (Catalog#10695-H08H )
Clone ID:2A4H7C11
Ig Type:Mouse IgG1
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Neurophilin-2 extracellular domain (rhNRP2; Catalog#10695-H08H; aa 1-855; NP_003863.2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Human NRP2 Antibody Usage Guide
Specificity:Human NRP2 / Neurophilin-2

ELISA: 0.5-1 μg/mL

This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect NRP2. The detection limit for NRP2 is approximately 5 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other NRP2 Antibody Products
NRP2/Neuropilin-2 Background

Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as formation of small lymphatic vessels and capillaries. Recent study has identified NRP-2 as a polysialylated protein expressed in human dendritic cells and modulates DC-T cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis and metastasis.

Human NRP2/Neuropilin-2 References
  • Chen H. et al., 1997, Neuron. 19: 547-59.
  • Bielenberg DR. et al., 2006, Exp Cell Res. 312: 584-93.
  • Yuan L. et al., 2002, Development. 129: 4797-806.
  • Benoit F. et al., 2006, Blood. 108: 1243-50.
  • Sabrina C. et al., 2007, J Biol Chem. 282: 30346-56.
  • Gray MJ. et al., 2008, J Natl Cancer Inst. 100: 109-20.
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    Catalog: 10695-MM01-50
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