Neuropilin-1 / NRP1 Protein (CD304 Protein)

Neuropilin-1

Neuropilin-1 / NRP1 Products

Neuropilin-1 / NRP1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Neuropilin-1/NRP1	Human	Neuropilin-1/NRP1/Fc Protein, Recombinant	10011-H02H
Neuropilin-1/NRP1	Human	Neuropilin-1 / NRP1 / CD304 Protein, Recombinant	10011-H08H

  10011-H02H:  Measured by its ability to bind with recombinant human VEGF165 in a functional ELISA.

Neuropilin-1 / NRP1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Neuropilin-1/NRP1	Human	Homo sapiens Neuropilin-1/NRP1 transcript variant 2 cDNA Clone(NM_001024628.2)	HG10011-M
Neuropilin-1/NRP1	Human	Human Neuropilin-1 transcript variant 2 ORF Expression Clone, Myc-tagged	HG10011-M-M
Neuropilin-1/NRP1	Human	NRP1 transcript variant 3 cDNA Clone / ORF Clone	HG13279-G
Neuropilin-1/NRP1	Mouse	Neuropilin-1 cDNA Clone / ORF Clone	MG50509-M
Neuropilin-1/NRP1	Rat	Neuropilin-1 cDNA Clone / ORF Clone	RG80056-M

Neuropilin-1 / NRP1 Related Areas

Neuroscience>>Axon Guidance>>Semaphorin & Related Molecules>>Neuropilin-1/NRP1

Cancer>>Growth factor & Receptor>>VEGF & Receptor>>Neuropilin-1/NRP1

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>Neuropilin-1/NRP1

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells>>Neuropilin-1/NRP1/CD304

Neuropilin-1 / NRP1 Alternative Names

Neuropilin-1, NRP1, VEGF165R, BDCA4, CD304, RP11-342D11.1, DKFZp686A03134, DKFZp781F1414, NP1, NRP [Homo sapiens]

Neuropilin-1, Nrp1, C530029I03, NP-1, NPN-1, Npn1, Nrp [Mus musculus]

Neuropilin-1 / NRP1 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
VEGF/VEGF-A	Human	VEGF 165 Protein, Recombinant
VEGF-C	Human	VEGF-C Protein, Recombinant
VEGF-D	Human	VEGF-D Protein, Recombinant
VEGFR3/FLT-4	Human	VEGFR3/FLT-4/Fc Protein, Recombinant
VEGFR3/FLT-4	Human	VEGFR3/FLT-4 Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human VEGFR3/FLT-4	ELISA	Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
VEGF/VEGF-A	Human	Homo sapiens VEGF transcript variant 2 cDNA Clone(NM_003376.4)
VEGF/VEGF-A	Human	Homo sapiens VEGF transcript variant 3 cDNA Clone(NM_001025367.1)
VEGF/VEGF-A	Human	Homo sapiens VEGF transcript variant 6 cDNA Clone(NM_001025370.1)
VEGF-B	Human	Homo sapiens VEGF-B cDNA Clone(NM_003377.3)
VEGF-C	Human	Homo sapiens VEGF-C cDNA Clone(NM_005429.2)
VEGF-D	Human	Homo sapiens VEGF-D cDNA Clone(NM_004469.2)
VEGFR1/Flt-1	Human	Homo sapiens VEGFR1/Flt-1 cDNA Clone(NM_002019.3)

Neuropilin-1 / NRP1 Background

Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a short cytoplasmic region. Neuropilin-1 (NRP1) acts as a receptor for two different extracellular ligands, class 3 semaphorins and specific isoforms of vascular endothelial growth factor. The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they promote angiogenesis and cell migration. Neuropilin-1 is likely to mediate contacts between the dendritic cells and the T lymphocytes via homotypic interactions and is essential for the initiation of the primary immune response. NRP1 is a co-receptor for VEGF receptor-2 (VEGFR2) that enhances the binding of VEGF165 to VEGFR2 and VEGF165-mediated chemotaxis. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors. Overexpression of NRPI in rat tumor cells results in enlarged tumors and substantially enhanced tumor angiogenesis. On the other hand, soluble NRP1 (sNRP1) is an antagonist of tumor angiogenesis.

Neuropilin-1 / NRP1 Related Studies

1. Nakamura F, et al. (2002) Structural and functional relation of neuropilins. Adv Exp Med Biol. 515: 55-69.
2. Romeo PH, et al. (2002) Neuropilin-1 in the immune system. Adv Exp Med Biol. 515: 49-54.
3. Klagsbrun M, et al. (2002) The role of neuropilin in vascular and tumor biology. Adv Exp Med Biol. 515: 33-48.
4. Staton CA, et al. (2007) Neuropilins in physiological and pathological angiogenesis. J Pathol. 212(3): 237-48.
5. Bagri A, et al. (2009) Neuropilins in tumor biology. Clin Cancer Res. 15(6): 1860-4.