Quick Order

Text Size:AAA

Neuropilin-1 / NRP1 / CD304 Antibody, Rabbit PAb, Antigen Affinity Purified

DatasheetReviewsRelated ProductsProtocols
Human NRP1 Antibody Product Information
Immunogen:Recombinant Human Neuropilin-1 / NRP1 / CD304 protein (Catalog#10011-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:Produced in rabbits immunized with purified, recombinant Human Neuropilin-1 / NRP1 / CD304 (rh Neuropilin-1 / NRP1 / CD304; Catalog#10011-H08H; NP_001019799.1; Met1-Lys644). Neuropilin-1 / NRP1 / CD304 specific IgG was purified by Human Neuropilin-1 / NRP1 / CD304 affinity chromatography.
Human NRP1 Antibody Usage Guide
Specificity:Human Neuropilin-1 / NRP1 / CD304
Application:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human Neuropilin-1 / NRP1 / CD304. The detection limit for Human Neuropilin-1 / NRP1 / CD304 is 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other NRP1 Antibody Products
Reactivity: Human  
Application: ELISA  IHC-P  
  • Slide 1
  • Slide 1
  • Slide 1
10011-R042-100
10011-R042-50
100 µg 
50 µg 
Add to Cart
Reactivity: Human  
Application: FCM  
  • Slide 1
10011-MM01-P-100
10011-MM01-P-50
100 Tests 
50 Tests 
Add to Cart
Reactivity: Human  
Application: FCM  
  • Slide 1
10011-MM01-A-100
10011-MM01-A-50
100 Tests 
50 Tests 
Add to Cart
Reactivity: Human  
Application: FCM  
  • Slide 1
10011-MM01-100
10011-MM01-50
100 µg 
50 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10011-RP01-100
    10011-RP01-200
    100 µg 
    200 µg 
    Add to Cart
    Neuropilin-1/NRP1/CD304 Background

    Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a short cytoplasmic region. Neuropilin-1 (NRP1) acts as a receptor for two different extracellular ligands, class 3 semaphorins and specific isoforms of vascular endothelial growth factor. The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they promote angiogenesis and cell migration. Neuropilin-1 is likely to mediate contacts between the dendritic cells and the T lymphocytes via homotypic interactions and is essential for the initiation of the primary immune response. NRP1 is a co-receptor for VEGF receptor-2 (VEGFR2) that enhances the binding of VEGF165 to VEGFR2 and VEGF165-mediated chemotaxis. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors. Overexpression of NRPI in rat tumor cells results in enlarged tumors and substantially enhanced tumor angiogenesis. On the other hand, soluble NRP1 (sNRP1) is an antagonist of tumor angiogenesis.

    Human Neuropilin-1/NRP1/CD304 References
  • Nakamura F, et al. (2002) Structural and functional relation of neuropilins. Adv Exp Med Biol. 515: 55-69.
  • Romeo PH, et al. (2002) Neuropilin-1 in the immune system. Adv Exp Med Biol. 515: 49-54.
  • Klagsbrun M, et al. (2002) The role of neuropilin in vascular and tumor biology. Adv Exp Med Biol. 515: 33-48.
  • Staton CA, et al. (2007) Neuropilins in physiological and pathological angiogenesis. J Pathol. 212(3): 237-48.
  • Bagri A, et al. (2009) Neuropilins in tumor biology. Clin Cancer Res. 15(6): 1860-4.
  • Product nameProduct name
    Size / Price
    Catalog: 10011-T16-50
    List Price: 
    Price:      (You Save: )
    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"