Neuroligin 3 (NLGN3)

Neuroligin 3 (NLGN3) is a member of the type-B carboxylesterase/lipase family. Neuroligins (NLGNs) are a family of presumptive postsynaptic cell adhesion molecules. Neuroligins (NLs) constitute a family of cell-surface proteins that interact with neurexins (beta-Nxs), another class of neuronal cell-surface proteins, one of each class functioning together in synapse formation. Neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons. NLGN1 and NLGN2 isoforms are concentrated at glutamatergic and GABAergic synapses, respectively, but the cellular expression and synaptic localization of the endogenous. Neuroligin 3 was enriched in brain, where Neuroligin 3 protein levels increased during postnatal development, coinciding with the peak of synaptogenesis. Neuroligin 3 is a synaptic adhesion molecule that is a shared component of glutamatergic and GABAergic synapses. Mutations in NLGN3 gene may be associated with autism and Asperger syndrome.

Neuroligin 3 (NLGN3) Related Areas

Neuroscience>>Synaptic Protein>>Neuroligin 3/NLGN3

Neuroligin 3 (NLGN3) Alternative Names

Neuroligin 3, NLGN3, HNL3, KIAA1480 [Homo sapiens]

Neuroligin 3, Nlgn3, RP23-440J15.4, A230085M13Rik, HNL3, NL3 [Mus musculus]

Summaries for Neuroligin 3 (NLGN3)

Entrez Gene summary for NLGN3:

This NLGN3 gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this NLGN3 gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]

OMIM - description for Neuroligin 3:

Neuroligins constitute a family of proteins thought to mediate cell-to-cell interactions between neurons (see NLGN1; 600568). Neuroligins function as ligands for the neurexin family of cell surface receptors (see 600565).

Wikipedia summary for Neuroligin 3:

Neuroligin 3 is a protein that in humans is encoded by the NLGN3 gene.
This NLGN3 gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.

Human Neuroligin 3 (NLGN3) Protein General Information

 

• Protein names: Neuroligin-3
• Sequence length: 848 AA.
• Sequence similarities: Neuroligin 3 belongs to the type-B carboxylesterase/lipase family.
• Sequence caution: The sequence AAF71231.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
  The sequence BAA96004.1 differs from that shown. Reason: Erroneous initiation.
  The sequence BAC11226.1 differs from that shown. Reason: Erroneous initiation.
• Subunit structure: Neuroligin 3 interacts with neurexin 1-beta, neurexin 2-beta and neurexin 3-beta. Neuroligin 3 probably interacts through its C-terminus with DLG4/PSD-95 third PDZ domain.
• Subcellular location: Membrane; Single-pass type I membrane protein
• Tissue specificity: Neuroligin 3 is expressed in the blood vessel walls (at protein level).
• Involvement in disease: Defects in Neuroligin 3 may be the cause of susceptibility to autism X-linked type 1 (AUTSX1) [MIM:300425]. AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age.
  Defects in Neuroligin 3 may be the cause of susceptibility to X-linked Asperger syndrome 1 (ASPGX1) [MIM:300494]. ASPGX1 is considered to be a form of childhood autism.

General information above from UniProt

Function for Neuroligin 3 (NLGN3) Protein

UniProtKB:

Neuroligin 3 is neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Neuroligin 3 may play a role in formation or maintenance of synaptic junctions. Neuroligin 3 may also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.

Genatlas:

• Neuroligin 3 is potential mediator of cell-cell interactions between neurons
• Neuroligin 3 triggers presynaptic development in contacting axon and playing a role in synaptic cell adhesion
• Neuroligin 3 is postsynaptic adhesion protein that control the maturation and function of synapses in the central nervous system (CNS)

Homology for human Neuroligin 3 (NLGN3)

• homolog to rattus Neuroligin

Phenotype Information for Neuroligin 3 (NLGN3)

• Gene/Locus: NLGN3, ASPGX1, AUTSX1
• Phenotype: {Asperger syndrome susceptibility, X-linked 1}
  {Autism susceptibility, X-linked 1}

Phenotype Information for Neuroligin 3 from OMIM (Online Mendelian Inheritance in Man)