Neuroligin 3 Protein & Antibody (NLGN3 Protein)

Neuroligin 3 Products

Neuroligin 3 Protein, Recombinant

Molecule	Species	Description	Cat. No
Neuroligin 3/NLGN3	Human	Neuroligin 3/NLGN3 Protein, Recombinant	11160-H08H

Neuroligin 3 Antibody

Molecule	Application	Description	Cat. No
Human Neuroligin 3/NLGN3	WB, ELISA	Neuroligin 3 / NLGN3 Antibody	11160-RP01
Human Neuroligin 3/NLGN3	WB, ELISA	Neuroligin 3 / NLGN3 Antibody (Antigen Affinity Purified)	11160-RP02

Neuroligin 3 cDNA Clone

Molecule	Species	Description	Cat. No
Neuroligin 3/NLGN3	Human	Homo sapiens Neuroligin 3/NLGN3 cDNA Clone	HG11160-M

Neuroligin 3 Related Areas

Neuroscience>>Synaptic Protein>>Neuroligin 3/NLGN3

Neuroligin 3 Alternative Names

Neuroligin 3, NLGN3, HNL3, KIAA1480 [Homo sapiens]

Neuroligin 3, Nlgn3, RP23-440J15.4, A230085M13Rik, HNL3, NL3 [Mus musculus]

Neuroligin 3 Background

Neuroligin 3 (NLGN3) is a member of the type-B carboxylesterase/lipase family. Neuroligins (NLGNs) are a family of presumptive postsynaptic cell adhesion molecules. Neuroligins (NLs) constitute a family of cell-surface proteins that interact with neurexins (beta-Nxs), another class of neuronal cell-surface proteins, one of each class functioning together in synapse formation. Neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons. NLGN1 and NLGN2 isoforms are concentrated at glutamatergic and GABAergic synapses, respectively, but the cellular expression and synaptic localization of the endogenous. NLGN3 was enriched in brain, where NLGN3 protein levels increased during postnatal development, coinciding with the peak of synaptogenesis. The NLGN3 is a synaptic adhesion molecule that is a shared component of glutamatergic and GABAergic synapses. Mutations in NLGN3 gene may be associated with autism and Asperger syndrome.

Neuroligin 3 Related Studies

1. Chih B, et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science. 307(5713): 1324-8.
2. Paraoanu LE, et al. (2006) Expression patterns of neurexin-1 and neuroligins in brain and retina of the chick embryo: Neuroligin-3 is absent in retina. Neurosci Lett. 395(2): 114-7.
3. Budreck EC, et al. (2007) Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses. Eur J Neurosci. 26(7): 1738-48.
4. Suckow AT, et al. (2008) Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology. 149(12): 6006-17.