Anti-Neuroligin 1 Antibody

Cat: 11617-R079
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Anti-Neuroligin 1 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-Neuroligin 1 Antibody
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Neuroligin 1
Immunogen
Recombinant Human Neuroligin 1 / NLGN1 protein (Catalog#11617-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Neuroligin 1 / NLGN1 (rh Neuroligin 1 / NLGN1; Catalog#11617-H08H; NP_055747.1; Met1-Ser677).
Source
Monoclonal Rabbit IgG Clone #079
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Neuroligin 1 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
IHC-P 1:100-1:500  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Neuroligin 1 Antibody (Rabbit Monoclonal antibody) Images
Human Neuroligin 1/NLGN1 Immunohistochemistry(IHC) 3853
Immunochemical staining of human NLGN1 in human brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Anti-Neuroligin 1 Antibody Alternative Names
Anti-NL1 Antibody
Neuroligin 1 Background Information

Neuroligin 1 (NLGN1) belongs to the type-B carboxylesterase/lipase family, is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. Neuroligins consist of five members (NLGN1, NLGN2, NLGN3, NLGN4 and NLGN4Y), which interact with beta-neurexins and this interaction is involved in the formation of functional synapses. The extracellular domain of functional Neuroligin 1 associates as a dimer when analyzed by sedimentation equilibrium. Neuroligin 1 has a unique N-linked glycosylation pattern in the neuroligin family, and glycosylation and its processing modify neuroligin activity. Neuroligin 1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. The persistent expression of Neuroligin 1 is required for the maintenance of NMDAR-mediated synaptic transmission, which enables normal development of synaptic plasticity and long-term memory in the amygdala of adult animals.

Full Name
neuroligin 1
References
  • Song JY, et al. (1999) Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses. Proc Natl Acad Sci U S A. 96(3): 1100-5.
  • Comoletti D, et al. (2003) Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. J Biol Chem. 278(50): 50497-505.
  • Ylisaukko-oja T, et al. (2005) Analysis of four neuroligin genes as candidates for autism. Eur J Hum Genet. 13(12): 1285-92.
  • Kim J, et al. (2008) Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals. Proc Natl Acad Sci U S A. 105(26): 9087-92.
  • Schapitz IU, et al. (2010) Neuroligin 1 is dynamically exchanged at postsynaptic sites. J Neurosci. 30(38): 12733-44.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Neuroligin 1 Antibody Rabbit Monoclonal ELISA 11617-R001
    Anti-Neuroligin 1 Antibody Rabbit Polyclonal ELISA 11617-RP02
    Anti-Neuroligin 1 Antibody Rabbit Polyclonal ELISA 11617-RP01
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